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dc.contributor.author | Lope Carvajal, Virginia | |
dc.contributor.author | Martín, Miguel | |
dc.contributor.author | Castelló Pastor, Adela | |
dc.contributor.author | Ruiz, Amparo | |
dc.contributor.author | Casas, Ana Mª | |
dc.contributor.author | Baena-Cañada, José Manuel | |
dc.contributor.author | Antolín, Silvia | |
dc.contributor.author | Ramos-Vázquez, Manuel | |
dc.contributor.author | García-Sáenz, José Ángel | |
dc.contributor.author | Muñoz, Montserrat | |
dc.contributor.author | Lluch, Ana | |
dc.contributor.author | de Juan-Ferré, Ana | |
dc.contributor.author | Jara, Carlos | |
dc.contributor.author | Sánchez-Rovira, Pedro | |
dc.contributor.author | Antón, Antonio | |
dc.contributor.author | Chacón, José Ignacio | |
dc.contributor.author | Arcusa, Angels | |
dc.contributor.author | Jimeno, Mª Angeles | |
dc.contributor.author | Bezares, Susana | |
dc.contributor.author | Vioque, Jesus | |
dc.contributor.author | Carrasco, Eva | |
dc.contributor.author | Perez-Gomez, Beatriz | |
dc.contributor.author | Pollan-Santamaria, Marina | |
dc.date.accessioned | 2019-03-15T14:10:43Z | |
dc.date.available | 2019-03-15T14:10:43Z | |
dc.date.issued | 2019-03-07 | |
dc.identifier.citation | Sci Rep. 2019 Mar 7;9(1):3904. | es_ES |
dc.identifier.issn | 2045-2322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7346 | |
dc.description.abstract | This study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account the individual energy needs of Spanish women. We conducted a multicenter matched case-control study where 973 pairs completed lifestyle and food frequency questionnaires. Expected caloric intake was predicted from a linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate as an offset and physical activity as explanatory. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. The association with BC risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. While premenopausal women that consumed few calories (>20% below predicted) had lower BC risk (OR = 0.36; 95% CI = 0.21-0.63), postmenopausal women with an excessive intake (≥40% above predicted) showed an increased risk (OR = 2.81; 95% CI = 1.65-4.79). For every 20% increase in relative (observed/predicted) caloric intake the risk of hormone receptor positive (p-trend < 0.001) and HER2+ (p-trend = 0.015) tumours increased 13%, being this figure 7% for triple negative tumours. While high energy intake increases BC risk, caloric restriction could be protective. Moderate caloric restriction, in combination with regular physical activity, could be a good strategy for BC prevention. | es_ES |
dc.description.sponsorship | This study was funded by Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association Against Cancer 2006 & 2016), Sociedad Española de Oncología Médica (SEOM) (Spanish Society of Medical Oncology), Ministerio de Economía y Competitividad (Spanish Ministry of Economy and Competitiveness. IJCI-2014–20900), Fundación Cerveza y Salud 2005 (Beer and Health Foundation 2005) and Federación de Asociaciones de Mujeres con Cáncer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Overeating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM study | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30846706 | es_ES |
dc.format.volume | 9 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 3904 | es_ES |
dc.identifier.doi | 10.1038/s41598-019-39346-4 | es_ES |
dc.contributor.funder | Asociación Española Contra el Cáncer | |
dc.contributor.funder | Sociedad Española de Oncología Médica | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Federación Española de Cáncer de Mama | |
dc.contributor.funder | Fundación Cerveza y Salud | |
dc.contributor.funder | Federación de Asociaciones de Mujeres con Cáncer de Mama | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-019-39346-4 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/IJCI-2014–20900 | es_ES |
dc.rights.accessRights | open access | es_ES |