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dc.contributor.authorLope Carvajal, Virginia 
dc.contributor.authorMartín, Miguel
dc.contributor.authorCastelló Pastor, Adela 
dc.contributor.authorRuiz, Amparo
dc.contributor.authorCasas, Ana Mª
dc.contributor.authorBaena-Cañada, José Manuel
dc.contributor.authorAntolín, Silvia
dc.contributor.authorRamos-Vázquez, Manuel
dc.contributor.authorGarcía-Sáenz, José Ángel
dc.contributor.authorMuñoz, Montserrat
dc.contributor.authorLluch, Ana
dc.contributor.authorde Juan-Ferré, Ana
dc.contributor.authorJara, Carlos
dc.contributor.authorSánchez-Rovira, Pedro
dc.contributor.authorAntón, Antonio
dc.contributor.authorChacón, José Ignacio
dc.contributor.authorArcusa, Angels
dc.contributor.authorJimeno, Mª Angeles
dc.contributor.authorBezares, Susana
dc.contributor.authorVioque, Jesus
dc.contributor.authorCarrasco, Eva
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorPollan-Santamaria, Marina 
dc.date.accessioned2019-03-15T14:10:43Z
dc.date.available2019-03-15T14:10:43Z
dc.date.issued2019-03-07
dc.identifier.citationSci Rep. 2019 Mar 7;9(1):3904.es_ES
dc.identifier.issn2045-2322es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7346
dc.description.abstractThis study analyzes the association of excessive energy intake and caloric restriction with breast cancer (BC) risk taking into account the individual energy needs of Spanish women. We conducted a multicenter matched case-control study where 973 pairs completed lifestyle and food frequency questionnaires. Expected caloric intake was predicted from a linear regression model in controls, including calories consumed as dependent variable, basal metabolic rate as an offset and physical activity as explanatory. Overeating and caloric restriction were defined taking into account the 99% confidence interval of the predicted value. The association with BC risk, overall and by pathologic subtype, was evaluated using conditional and multinomial logistic regression models. While premenopausal women that consumed few calories (>20% below predicted) had lower BC risk (OR = 0.36; 95% CI = 0.21-0.63), postmenopausal women with an excessive intake (≥40% above predicted) showed an increased risk (OR = 2.81; 95% CI = 1.65-4.79). For every 20% increase in relative (observed/predicted) caloric intake the risk of hormone receptor positive (p-trend < 0.001) and HER2+ (p-trend = 0.015) tumours increased 13%, being this figure 7% for triple negative tumours. While high energy intake increases BC risk, caloric restriction could be protective. Moderate caloric restriction, in combination with regular physical activity, could be a good strategy for BC prevention.es_ES
dc.description.sponsorshipThis study was funded by Fundación Científica Asociación Española Contra el Cancer (AECC) (Scientific Foundation of the Spanish Association Against Cancer 2006 & 2016), Sociedad Española de Oncología Médica (SEOM) (Spanish Society of Medical Oncology), Ministerio de Economía y Competitividad (Spanish Ministry of Economy and Competitiveness. IJCI-2014–20900), Fundación Cerveza y Salud 2005 (Beer and Health Foundation 2005) and Federación de Asociaciones de Mujeres con Cáncer de Mama (FECMA) (Spanish Federation of Associations of Women with Breast Cancer).es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleOvereating, caloric restriction and breast cancer risk by pathologic subtype: the EPIGEICAM studyes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30846706es_ES
dc.format.volume9es_ES
dc.format.number1es_ES
dc.format.page3904es_ES
dc.identifier.doi10.1038/s41598-019-39346-4es_ES
dc.contributor.funderAsociación Española Contra el Cáncer 
dc.contributor.funderSociedad Española de Oncología Médica 
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderFederación Española de Cáncer de Mama 
dc.contributor.funderFundación Cerveza y Salud 
dc.contributor.funderFederación de Asociaciones de Mujeres con Cáncer de Mama 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1038/s41598-019-39346-4es_ES
dc.identifier.journalScientific reportses_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/IJCI-2014–20900es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional