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dc.contributor.authorAguero, Jaume 
dc.contributor.authorIshikawa, Kiyotake
dc.contributor.authorFish, Kenneth M
dc.contributor.authorHammoudi, Nadjib
dc.contributor.authorHadri, Lahouaria
dc.contributor.authorGarcia-Alvarez, Ana 
dc.contributor.authorIbanez, Borja 
dc.contributor.authorFuster, Valentin 
dc.contributor.authorHajjar, Roger J
dc.contributor.authorLeopold, Jane A
dc.identifier.citationPLoS One. 2015; 10(4):e0124526es_ES
dc.descriptionThis work is supported by National Institutes of Health RO1 HL083156, HL093183, HL119046, P20HL100396 and a NHLBI Program of Excellence in Nanotechnology Award, Contract # HHSN268201000045C (RJH) and NIH R01 105301 (JAL). Part of the work was funded by a Leducq Foundation grant (RJH). JA was supported by the Fundacion Alfonso Martin-Escudero.es_ES
dc.description.abstractPulmonary hypertension (PH) is associated with aberrant vascular remodeling and right ventricular (RV) dysfunction that contribute to early mortality. Large animal models that recapitulate human PH are essential for mechanistic studies and evaluating novel therapies; however, these models are not readily accessible to the field owing to the need for advanced surgical techniques or hypoxia. In this study, we present a novel swine model that develops cardiopulmonary hemodynamics and structural changes characteristic of chronic PH. This percutaneous model was created in swine (n=6) by combining distal embolization of dextran beads with selective coiling of the lobar pulmonary arteries (2 procedures per lung over 4 weeks). As controls, findings from this model were compared with those from a standard weekly distal embolization model (n=6) and sham animals (n=4). Survival with the combined embolization model was 100%. At 8 weeks after the index procedure, combined embolization procedure animals had increased mean pulmonary artery pressure (mPA) and pulmonary vascular resistance (PVR) compared to the controls with no effect on left heart or systemic pressures. RV remodeling and RV dysfunction were also present with a decrease in the RV ejection fraction, increase in the myocardial performance index, impaired longitudinal function, as well as cardiomyocyte hypertrophy, and interstitial fibrosis, which were not present in the controls. Pulmonary vascular remodeling occurred in both embolization models, although only the combination embolization model had a decrease in pulmonary capacitance. Taken together, these cardiopulmonary hemodynamic and structural findings identify the novel combination embolization swine model as a valuable tool for future studies of chronic PH.es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCell Hypoxia es_ES
dc.subject.meshEmbolization, Therapeutic es_ES
dc.subject.meshHumans es_ES
dc.subject.meshHypertension, Pulmonary es_ES
dc.subject.meshMyocytes, Cardiac es_ES
dc.subject.meshPulmonary Artery es_ES
dc.subject.meshSwine es_ES
dc.subject.meshVentricular Dysfunction, Right es_ES
dc.subject.meshVentricular Remodeling es_ES
dc.subject.meshHemodynamics es_ES
dc.titleCombination proximal pulmonary artery coiling and distal embolization induces chronic elevations in pulmonary artery pressure in Swinees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderNational Institutes of Health (United States)es_ES
dc.contributor.funderFundación Alonso Martin-Escuderoes_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES

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