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dc.contributor.authorSegales, Jessica 
dc.contributor.authorPerdiguero, Eusebio
dc.contributor.authorMunoz-Canoves, Pura 
dc.date.accessioned2019-03-11T11:38:55Z
dc.date.available2019-03-11T11:38:55Z
dc.date.issued2016
dc.identifier.citationFront Cell Dev Biol. 2016; 4:91es_ES
dc.identifier.issn2296-634Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7314
dc.description.abstractFormation of skeletal muscle fibers (myogenesis) during development and after tissue injury in the adult constitutes an excellent paradigm to investigate the mechanisms whereby environmental cues control gene expression programs in muscle stem cells (satellite cells) by acting on transcriptional and epigenetic effectors. Here we will review the molecular mechanisms implicated in the transition of satellite cells throughout the distinct myogenic stages (i.e., activation from quiescence, proliferation, differentiation, and self-renewal). We will also discuss recent findings on the causes underlying satellite cell functional decline with aging. In particular, our review will focus on the epigenetic changes underlying fate decisions and on how the p38 MAPK signaling pathway integrates the environmental signals at the chromatin to build up satellite cell adaptive responses during the process of muscle regeneration, and how these responses are altered in aging. A better comprehension of the signaling pathways connecting external and intrinsic factors will illuminate the path for improving muscle regeneration in the aged.es_ES
dc.description.sponsorshipWork in the authors’ laboratory was supported by MINECO, Spain (SAF2015-67369-R, "María de Maeztu” Programme for Units of Excellence in R&D MDM-2014-0370), AFM, MDA, Convenio UPF-CNIC, E-RARE, Fundació Marató TV3. JS is recipient of a Juan de la Cierva postdoctoral fellowship.es_ES
dc.language.isoenges_ES
dc.publisherF1000Researches_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectaginges_ES
dc.subjectepigeneticses_ES
dc.subjectmuscle stem cellses_ES
dc.subjectp38 MAPKses_ES
dc.subjectsatellite cellses_ES
dc.subjecttissue regenerationes_ES
dc.titleRegulation of Muscle Stem Cell Functions: A Focus on the p38 MAPK Signaling Pathwayes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27626031es_ES
dc.format.volume4es_ES
dc.format.page91es_ES
dc.identifier.doi10.3389/fcell.2016.00091es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España)es_ES
dc.contributor.funderUniversidad Pompeu Fabraes_ES
dc.contributor.funderFundacio La Mataroes_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3389/fcell.2016.00091es_ES
dc.identifier.journalFrontiers in cell and developmental biologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio de Regeneración Tisulares_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-67369-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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