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dc.contributor.author | Mancheño-Corvo, Pablo | |
dc.contributor.author | Lopez-Santalla, Mercedes | |
dc.contributor.author | Menta, Ramon | |
dc.contributor.author | DelaRosa, Olga | |
dc.contributor.author | Mulero, Francisca | |
dc.contributor.author | Del Rio, Borja | |
dc.contributor.author | Ramirez, Cristina | |
dc.contributor.author | Büscher, Dirk | |
dc.contributor.author | Bueren, Juan A | |
dc.contributor.author | Lopez-Belmonte, Juan | |
dc.contributor.author | Dalemans, Wilfried | |
dc.contributor.author | Garin, Marina I | |
dc.contributor.author | Lombardo, Eleuterio | |
dc.date.accessioned | 2019-03-07T10:59:26Z | |
dc.date.available | 2019-03-07T10:59:26Z | |
dc.date.issued | 2017-04-21 | |
dc.identifier.citation | Front Immunol. 2017;8:462. | es_ES |
dc.identifier.issn | 1664-3224 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7297 | |
dc.description.abstract | Mesenchymal stem cells (MSCs) are multipotent stromal cells with immunomodulatory properties. They have emerged as a very promising treatment for autoimmunity and inflammatory diseases such as rheumatoid arthritis. Previous studies have demonstrated that MSCs, administered systemically, migrate to lymphoid tissues associated with the inflammatory site where functional MSC-induced immune cells with a regulatory phenotype were increased mediating the immunomodulatory effects of MSCs. These results suggest that homing of MSCs to the lymphatic system plays an important role in the mechanism of action of MSCs in vivo. Thus, we hypothesized that direct intralymphatic (IL) (also referred as intranodal) administration of MSCs could be an alternative and effective route of administration for MSC-based therapy. Here, we report the feasibility and efficacy of the IL administration of human expanded adipose mesenchymal stem cells (eASCs) in a mouse model of collagen-induced arthritis (CIA). IL administration of eASCs attenuated the severity and progression of arthritis, reduced bone destruction and increased the levels of regulatory T cells (CD25+Foxp3+CD4+ cells) and Tr1 cells (IL10+CD4+), in spleen and draining lymph nodes. Taken together, these results indicate that IL administration of eASCs is very effective in modulating established CIA and may represent an alternative treatment modality for cell therapy with eASCs. | es_ES |
dc.description.sponsorship | This project has received funding from the Spanish Ministerio de Economía y Competitividad and Comunidad Autónoma de Madrid to TiGenix and the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement No 279174 to TiGenix, CIEMAT, and Farma-Cros. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Frontiers Media | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | Adipose mesenchymal stem cells | es_ES |
dc.subject | Collagen-induced arthritis | es_ES |
dc.subject | Efficacy | es_ES |
dc.subject | Immunomodulation | es_ES |
dc.subject | Intralymphatic route | es_ES |
dc.subject.mesh | Adipose Tissue | es_ES |
dc.subject.mesh | Self Efficacy | es_ES |
dc.subject.mesh | Epithelial-Mesenchymal Transition | es_ES |
dc.subject.mesh | Arthritis | es_ES |
dc.subject.mesh | Immunomodulation | es_ES |
dc.title | Intralymphatic Administration of Adipose Mesenchymal Stem Cells Reduces the Severity of Collagen-Induced Experimental Arthritis | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28484460 | es_ES |
dc.format.volume | 8 | es_ES |
dc.format.page | 462 | es_ES |
dc.identifier.doi | 10.3389/fimmu.2017.00462 | es_ES |
dc.contributor.funder | Ministerio de Ciencia y Competitividad (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea. 7 Programa Marco | |
dc.description.peerreviewed | Sí | es_ES |
dc.relation.publisherversion | https://doi.org/ 10.3389/fimmu.2017.00462. | es_ES |
dc.identifier.journal | Frontiers in immunology | es_ES |
dc.repisalud.institucion | CNIO | es_ES |
dc.repisalud.orgCNIO | CNIO::Unidades técnicas::Unidad de Imagen Molecular | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/279174 | es_ES |
dc.rights.accessRights | open access | es_ES |