Por favor, use este identificador para citar o enlazar este Item:http://hdl.handle.net/20.500.12105/7266
Título
Robust, universal biomarker assay to detect senescent cells in biological specimens
Autor(es)
Fecha de publicación
2017-02
Cita
Aging Cell. 2017;16(1):192-197.
Idioma
Inglés
Tipo de documento
journal article
Resumen
Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain unsatisfactory. Here, we designed and synthesized a lipophilic, biotin-linked Sudan Black B (SBB) analogue suitable for sensitive and specific, antibody-enhanced detection of lipofuscin-containing senescent cells in any biological material. This new hybrid histo-/immunochemical method is easy to perform, reliable, and universally applicable to assess senescence in biomedicine, from cancer research to gerontology.
Palabras clave
MESH
Animals | Biological Assay | Biomarkers | Biotin | Cell Line, Tumor | Humans | Mice | Cellular Senescence
Versión en línea
DOI
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