dc.contributor.author | Blanco-Rojo, Ruth | |
dc.contributor.author | Perez-Martinez, Pablo | |
dc.contributor.author | Lopez-Moreno, Javier | |
dc.contributor.author | Martinez-Botas, Javier | |
dc.contributor.author | Delgado-Lista, Javier | |
dc.contributor.author | van-Ommen, Ben | |
dc.contributor.author | Yubero-Serrano, Elena | |
dc.contributor.author | Camargo, Antonio | |
dc.contributor.author | Ordovas, Jose M | |
dc.contributor.author | Perez-Jimenez, Francisco | |
dc.contributor.author | Gomez-Coronado, Diego | |
dc.contributor.author | Lopez-Miranda, Jose | |
dc.date.accessioned | 2019-02-28T16:05:51Z | |
dc.date.available | 2019-02-28T16:05:51Z | |
dc.date.issued | 2017-10-02 | |
dc.identifier.citation | Sci Rep. 2017; 7(1):12499 | es_ES |
dc.identifier.issn | 2045-2322 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7262 | |
dc.description.abstract | This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator. During follow-up 106 individuals progressed to T2DM. The cholesterol efflux/apoA-1 ratio was inversely associated with T2DM development independently of traditional risk factors (model-1, OR: 0.647, 95%CI: 0.495-0.846), and after additional adjustment for glycaemic parameters (model-2, OR: 0.670, 95%CI: 0.511-0.878). When cumulative incidence of diabetes was analysed by quartiles of cholesterol efflux/apoA-I, incidence of T2DM was reduced by 54% in subjects who were in the higher cholesterol efflux/apoA-I quartile compared to subjects in the lowest quartile (p = 0.018 and p = 0.042 for model-1 and 2). Moreover, participants who were in the higher cholesterol efflux/apoA-I presented significantly higher disposition index (β = 0.056, SE = 0.026; p = 0.035). In conclusion, HDL-cholesterol efflux normalised to apoA-I was inversely associated with T2DM development in cardiovascular patients. This association was independent of several T2DM risk factors, and may be related to a preserved beta-cell function. | es_ES |
dc.description.sponsorship | The authors would like to thank Veronica de Dios and Lorena Crespo of the Department of BiochemistryResearch, Hospital Universitario Ramon y Cajal, Instituto Ramon y Cajal de Investigacion Sanitaria (IRYCIS), for technical assistance. The authors also thank the volunteers who participated in the study. The present study was supported by the Ministerio de Economia y Competitividad, Spain (AGL2012/39615 and AGL2015-67896-P to J.L.-M.) and by the Ministerio de Ciencia e Innovacion, Spain (PI11/2077 to D.G.-C., PIE14/00005 to J.L.-M., PI13/00023 to J.D.-L. and PIE 14/00031 to CIBEROBN). It was also partly supported by a research grant from the European Commission (NUTRITECH European Integrated Project-289511). The CORDIOPREV study is supported by the Fundacion Patrimonio Comunal Olivarero. We also received additional funding from CITOLIVA, CEAS, Junta de Andalucia (Consejeria de Salud, Consejeria de Agricultura y Pesca, Consejeria de Innovacion, Ciencia y Empresa), Diputaciones de Jaen y Cordoba, Centro de Excelencia en Investigacion sobre Aceite de Oliva y Salud and Ministerio de Medio Ambiente, Medio Rural y Marino and the Spanish Government. The study was also co-financed by the Fondo Europeo de Desarrollo Regional (FEDER). The CIBEROBN is an initiative of the Instituto de Salud Carlos III, Madrid, Spain. The U.S. Department of Agriculture-Agricultural Research Service (ARS), under Agreement No. 58-1950-4-003 to J.M.O. The CNIC is supported by Ministerio de Economia y Competitividad, Spain, and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (Ministerio de Economia y Competitividad award SEV-2015-0505). R.B.-R. is supported by an ISCIII postdoctoral research contract (Sara Borrell). | es_ES |
dc.language.iso | eng | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | HDL cholesterol efflux normalised to apoA-I is associated with future development of type 2 diabetes: from the CORDIOPREV trial | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 28970513 | es_ES |
dc.format.volume | 7 | es_ES |
dc.format.number | 1 | es_ES |
dc.format.page | 12499 | es_ES |
dc.identifier.doi | 10.1038/s41598-017-12678-9 | es_ES |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Ministerio de Ciencia, Innovación y Universidades (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Fundación Patrimonio Comunal Olivarero | |
dc.contributor.funder | Regional Government of Andalusia (España) | |
dc.contributor.funder | Ministerio de Medio Ambiente (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | United States Department of Agriculture | |
dc.contributor.funder | Fundación ProCNIC | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 2045-2322 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1038/s41598-017-12678-9 | es_ES |
dc.identifier.journal | Scientific reports | es_ES |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionales | es_ES |
dc.repisalud.institucion | CNIC | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/289511/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AGL2012/39615 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/AGL2015-67896-P | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI11/2077 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PIE14/00005 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI13/00023 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PIE14/00031 | es_ES |
dc.rights.accessRights | open access | es_ES |