Show simple item record

dc.contributor.authorPavillard, Luís E
dc.contributor.authorCañadas-Lozano, Diego
dc.contributor.authorAlcocer-Gómez, Elísabet
dc.contributor.authorMarín-Aguilar, Fabiola
dc.contributor.authorPereira, Sheila
dc.contributor.authorRobertson, Avril A B
dc.contributor.authorMuntané, Jordi
dc.contributor.authorRyffel, Bernhard
dc.contributor.authorCooper, Matthew A
dc.contributor.authorQuiles, José L
dc.contributor.authorBullón, Pedro
dc.contributor.authorRuiz-Cabello, Jesus 
dc.contributor.authorCordero, Mario D
dc.date.accessioned2019-02-28T15:37:44Z
dc.date.available2019-02-28T15:37:44Z
dc.date.issued2017-11-21
dc.identifier.citationOncotarget. 2017; 8(59):99740-99756es_ES
dc.identifier.issn1949-2553es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7259
dc.description.abstractThe NLRP3-inflammasome complex has emerged as an important component of inflammatory processes in metabolic dysfunction induced by high-caloric diets. In this study, we investigate the molecular mechanisms by which NLRP3 inhibition may attenuate diet-induced cardiac injury. Here we show the cardiac damage induced by high sugar diet (HSD), high fat diet (HFD) or high sugar/fat diet (HSFD) over 15 weeks. Genetic ablation of NLRP3 protected against this damage by autophagy induction and apoptotic control. Furthermore, NLRP3 inhibition by the selective small molecule MCC950 resulted in similar autophagy induction and apoptotic control in hearts after diets. These data were reproduced in THP-1 cells treated with MCC950 and cultured in media supplemented with serum from mice dosed with MCC950 and fed with diets. NLRP3 inhibition exerted beneficial metabolic, and autophagic adaptations in hearts from obesogenic diets. The inhibition of NLRP3 activation may hold promise in the treatment of metabolic and cardiovascular diseases.es_ES
dc.description.sponsorshipThis study was supported by a grant from the Andalusian regional government (Grupo de Investigacion Junta de Andalucia CTS113), Consejería de Salud de la Junta de Andalucia: PI-0036-2014.es_ES
dc.language.isoenges_ES
dc.publisherImpact Journalses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMCC950es_ES
dc.subjectNLRP3-inflammasomees_ES
dc.subjectautophagyes_ES
dc.subjectcardiac damagees_ES
dc.titleNLRP3-inflammasome inhibition prevents high fat and high sugar diets-induced heart damage through autophagy inductiones_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29245937es_ES
dc.format.volume8es_ES
dc.format.number59es_ES
dc.format.page99740-99756es_ES
dc.identifier.doi10.18632/oncotarget.20763es_ES
dc.contributor.funderJunta de Andalucíaes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1949-2553es_ES
dc.relation.publisherversionhttps://doi.org/10.18632/oncotarget.20763es_ES
dc.identifier.journalOncotargetes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicases_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


Files in this item

Acceso Abierto
Thumbnail
Acceso Abierto
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional