Show simple item record

dc.contributor.authorNieto, Amelia
dc.contributor.authorPozo Sanchez, Francisco 
dc.contributor.authorVidal-García, Matxalen
dc.contributor.authorOmeñaca, Manuel
dc.contributor.authorCasas Flecha, Inmaculada 
dc.contributor.authorFalcon, Ana
dc.identifier.citationFront Microbiol. 2017 Apr 3;8:575.es_ES
dc.descriptionCorrigendum: Identification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenza. Front Microbiol. 2017 Jun 15;8:1080. doi: 10.3389/fmicb.2017.01080. PMID: 28626458
dc.description.abstractSeveral amino acid changes have been previously implicated in adaptation of avian influenza viruses to human hosts, among them the D701N change in the PB2 polymerase subunit that also is the main determinant of avian virus pathogenesis in animal models. However, previous studies using recombinant viruses did not provide conclusive information of the contribution of this PB2 residue to pathogenicity in human influenza virus strains. We identified this mutation in an A(H1N1)pdm09-like human influenza virus isolated from an infected patient with pneumonia and acute respiratory failure, admitted to the intensive care unit. An exhaustive search has revealed PB2-D701 as a highly conserved position in all available H1N1 human virus sequences in NCBI database, showing a very low prevalence of PB2-D701N change. Presence of PB2-701N amino acid correlates with severe or fatal outcome in those scarce cases with known disease outcome of the infection. In these patients, the residue PB2-701N may contribute to pathogenicity as it was previously reported in humans infected with avian viruses. This study helps to clarify a debate that has arisen regarding the role of PB2-D701N in human influenza virus pathogenicity.es_ES
dc.description.sponsorshipFunding. This work was supported by the Spanish Ministry of Economy, Industry and Competitiveness, Plan Nacional de Investigacion Científica, Desarrollo e Innovación Tecnológica (BFU2014-57797-R) and the network Ciber de Enfermedades Respiratorias (CIBERES) to AN.es_ES
dc.publisherFrontiers Media es_ES
dc.subjectD701N mutationes_ES
dc.subjectPB2 subunites_ES
dc.subjectAdaptation of avian viruseses_ES
dc.subjectInfluenza viruses_ES
dc.titleIdentification of Rare PB2-D701N Mutation from a Patient with Severe Influenza: Contribution of the PB2-D701N Mutation to the Pathogenicity of Human Influenzaes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderInstituto de Salud Carlos III 
dc.identifier.journalFrontiers in microbiologyes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

Files in this item

Acceso Abierto
Acceso Abierto

This item appears in the following Collection(s)

Show simple item record

Atribución 4.0 Internacional
This item is licensed under a: Atribución 4.0 Internacional