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dc.contributor.authorIvanovitch, Kenzo 
dc.contributor.authorEsteban, Isaac 
dc.contributor.authorTorres, Miguel 
dc.date.accessioned2019-02-25T13:15:05Z
dc.date.available2019-02-25T13:15:05Z
dc.date.issued2017-11-22
dc.identifier.citationJ Cardiovasc Dev Dis. 2017; 4(4):20es_ES
dc.identifier.issn2308-3425es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7233
dc.description.abstractIn this review, we will focus on the growth and morphogenesis of the developing heart, an aspect of cardiovascular development to which Antoon Moorman and colleagues have extensively contributed. Over the last decades, genetic studies and characterization of regionally regulated gene programs have provided abundant novel insights into heart development essential to understand the basis of congenital heart disease. Heart morphogenesis, however, is inherently a complex and dynamic three-dimensional process and we are far from understanding its cellular basis. Here, we discuss recent advances in studying heart morphogenesis and regionalization under the light of the pioneering work of Moorman and colleagues, which allowed the reinterpretation of regional gene expression patterns under a new morphogenetic framework. Two aspects of early heart formation will be discussed in particular: (1) the initial formation of the heart tube and (2) the formation of the cardiac chambers by the ballooning process. Finally, we emphasize that in addition to analyses based on fixed samples, new approaches including clonal analysis, single-cell sequencing, live-imaging and quantitative analysis of the data generated will likely lead to novel insights in understanding early heart tube regionalization and morphogenesis in the near future.es_ES
dc.description.sponsorshipThis work was supported by grants BFU2015-71519-P, BFU2015-70193-REDT and RD16/0011/0019 (ISCIII) from the Spanish Ministry of Economy, Industry and Competitiveness (MEIC). KI was supported by a Human Frontiers Science Program (LT000609/2015) and EMBO (ATL1275-2014) postdoctoral fellowships. IE is supported by an FPI predoctoral contract from MEIC. The CNIC is supported by the Spanish MEIC and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505)es_ES
dc.language.isoenges_ES
dc.publisherMultidisciplinary Digital Publishing Institute (MDPI) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCardiac crescentes_ES
dc.subjectCardiac differentiationes_ES
dc.subjectCardiomyocytees_ES
dc.subjectFirst heart fieldes_ES
dc.subjectHeart tubees_ES
dc.subjectLive-imaginges_ES
dc.subjectSecond heart fieldes_ES
dc.titleGrowth and Morphogenesis during Early Heart Development in Amnioteses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29367549es_ES
dc.format.volume4es_ES
dc.format.number4es_ES
dc.format.page20es_ES
dc.identifier.doi10.3390/jcdd4040020es_ES
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderEuropean Molecular Biology Organization 
dc.contributor.funderInternational Human Frontier Science Program Organization 
dc.contributor.funderFundación ProCNIC 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2308-3425es_ES
dc.relation.publisherversionhttps://doi.org/10.3390/jcdd4040020es_ES
dc.identifier.journalJournal of cardiovascular development and diseasees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganoses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2015-71519-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2015-70193-REDTes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0011/0019es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional