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dc.contributor.authorGasull-Camós, Júlia
dc.contributor.authorSoto-Montenegro, Maria Luisa
dc.contributor.authorCasquero-Veiga, Marta
dc.contributor.authorDesco, Manuel 
dc.contributor.authorArtigas, Francesc
dc.contributor.authorCastañé, Anna
dc.date.accessioned2019-02-25T11:01:30Z
dc.date.available2019-02-25T11:01:30Z
dc.date.issued2017
dc.identifier.citationInt J Neuropsychopharmacol. 2017; 20(12):988-993es_ES
dc.identifier.issn1461-1457es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7228
dc.description.abstractBackground: Glutamatergic neurotransmission has emerged as a novel target in antidepressant drug development, with a critical role of the ventral anterior cingulate cortex. We recently reported that blockade of the astrocytic glutamate transporter GLT-1 with dihydrokainic acid in infralimbic cortex (rodent equivalent of ventral anterior cingulate cortex), but not in the adjacent prelimbic cortex, evoked robust antidepressant-like effects through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor activation and increased serotonin release. Methods: 2-deoxy-2-[18F]-fluoro-D-glucose-positron emission tomography and computed tomography in 36 male Wistar rats microinfused bilaterally in prelimbic cortex or infralimbic cortex with dihydrokainic acid or vehicle. Results: Dihydrokainic acid microinfusion in infralimbic cortex and prelimbic cortex evoked dramatically different regional patterns of subcortical activity. In infralimbic cortex, dihydrokainic acid selectively affected midbrain areas, whereas in prelimbic cortex it affected the basal ganglia, the thalamus, and both superior and inferior colliculi. Conclusions: These results highlight the differential connectivity of infralimbic and prelimbic cortex with subcortical brain regions and support the involvement of infralimbic cortex-midbrain pathway in the antidepressant-like effects of dihydrokainic acid.es_ES
dc.description.sponsorshipThis work was supported by Spanish Ministry of Economy and Competitiveness grants (SAF2012-35183, SAF2015-68346, ISCIII-FIS PI14/00860 and CPII14/00005, and BES2013-063241 J.GC.) cofinanced by European Regional Development Fund, Generalitat de Catalunya (2014-SGR798), Comunidad de Madrid (BRADE-CM S2013/ICE-2958), Mapfre foundation, Alicia Koplowitz Foundation (FAK16/01), and Centro de Investigación Biomédica en Red de Salud Mental.es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectFDG-PETes_ES
dc.subjectdihydrokainic acides_ES
dc.subjectglutamate transporter-1es_ES
dc.subjectinfralimbices_ES
dc.subjectprelimbices_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBrain Mapping es_ES
dc.subject.meshCerebral Cortex es_ES
dc.subject.meshExcitatory Amino Acid Agonists es_ES
dc.subject.meshExcitatory Amino Acid Transporter 2 es_ES
dc.subject.meshFluorodeoxyglucose F18 es_ES
dc.subject.meshKainic Acid es_ES
dc.subject.meshMale es_ES
dc.subject.meshNeural Pathways es_ES
dc.subject.meshPositron-Emission Tomography es_ES
dc.subject.meshRats es_ES
dc.subject.meshRats, Wistar es_ES
dc.subject.meshTomography Scanners, X-Ray Computed es_ES
dc.titleDifferential Patterns of Subcortical Activity Evoked by Glial GLT-1 Blockade in Prelimbic and Infralimbic Cortex: Relationship to Antidepressant-Like Effects in Ratses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID29016806es_ES
dc.format.volume20es_ES
dc.format.number12es_ES
dc.format.page988-993es_ES
dc.identifier.doi10.1093/ijnp/pyx067es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.contributor.funderComunidad de Madrides_ES
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBERes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1469-5111es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/ijnp/pyx067es_ES
dc.identifier.journalThe international journal of neuropsychopharmacologyes_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzadaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2012-35183es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-68346es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/00860es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CPII14/00005es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BES2013-063241es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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