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dc.contributor.authorYang, Xiaobo
dc.contributor.authorLupón, Josep
dc.contributor.authorVidán, Maria T
dc.contributor.authorFerguson, Caleb
dc.contributor.authorGastelurrutia, Paloma
dc.contributor.authorNewton, Phillip J
dc.contributor.authorMacdonald, Peter S
dc.contributor.authorBueno, Hector 
dc.contributor.authorBayes-Genis, Antoni
dc.contributor.authorWoo, Jean
dc.contributor.authorFung, Erik
dc.date.accessioned2019-02-25T08:36:06Z
dc.date.available2019-02-25T08:36:06Z
dc.date.issued2018-12-04
dc.identifier.citationJ Am Heart Assoc. 2018; 7(23):e008251es_ES
dc.identifier.issn2047-9980es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7225
dc.description.abstractBackground Although frailty has been associated with increased risks for hospitalization and mortality in chronic heart failure, the precise average effect remains uncertain. We performed a systematic review and meta-analysis to summarize the hazards for mortality and incident hospitalization in patients with heart failure and frailty compared with those without frailty and explored the heterogeneity underlying the effect size estimates. Methods and Results MEDLINE , EMBASE, and Cochrane databases were queried for articles published between January 1966 and March 2018. Predefined selection criteria were used. Hazard ratios ( HRs ) were pooled for meta-analyses, and where odds ratios were used previously, original data were recalculated for HR . Overlapping data were consolidated, and only unique data points were used. Study quality and bias were assessed. Eight studies were included for mortality (2645 patients), and 6 studies were included for incident hospitalization (2541 patients) during a median follow-up of 1.82 and 1.12 years, respectively. Frailty was significantly associated with an increased hazard for mortality ( HR , 1.54; 95% confidence interval, 1.34-1.75; P<0.001) and incident hospitalization ( HR , 1.56; 95% confidence interval, 1.36-1.78; P<0.001) in chronic heart failure. The Fried phenotype estimated a 16.9% larger effect size than the combined Fried/non-Fried frailty assessment for the end point of mortality ( HR , 1.80; 95% confidence interval, 1.41-2.28; P<0.001), but not for hospitalization ( HR , 1.57; 95% confidence interval, 1.30-1.89; P<0.001). Study heterogeneity was found to be low (I2=0%), and high quality of studies was verified by the Newcastle-Ottawa scale. Conclusions Overall, the presence of frailty in chronic heart failure is associated with an increased hazard for death and hospitalization by ≈1.5-fold.es_ES
dc.description.sponsorshipBayes-Genıs and Gastelurrutia are supported by grants from the Ministerio de Educacion y Ciencia (SAF2014-59892) and Generalitat de Catalunya (Pla estrategic de recerca i innovacio en salut Programme, Departament de Salut, SLT002_16_ 00209), Fundacio La MARATO de TV3 (201502-30, 20151610), Red de Terapia Celular–TerCel (RD16/0011/0006), and Centro de Investigacion en Red en Enfermedades Cardiovasculares (CB16/11/00403) projects as part of the Plan Nacional de I+D+I, and jointly funded by Instituto de Salud Carlos III– Sudireccion General de Evaluacion y el Fondo Europeo de Desarrollo Regional. Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Ministerio de Economıa, Industria y Competitividad (MINECO), and the ProCNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). Ferguson was supported by a University of Technology Sydney, Chancellor’s Postdoctoral Research Fellowship (2015001232). Fung is recipient of the Direct Grant award from the Faculty of Medicine, The Chinese University of Hong Kong, and of an investigator-initiated research grant from the Food and Health Bureau of the Hong Kong Special Administrative Region. Woo is supported by research grants from the Hong Kong Jockey Club and the Research Grants Council.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Heart Association (AHA) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/*
dc.subjectChronic heart failurees_ES
dc.subjectFrailtyes_ES
dc.subjectHospitalizationes_ES
dc.subjectMeta‐analysises_ES
dc.subjectMortalityes_ES
dc.titleImpact of Frailty on Mortality and Hospitalization in Chronic Heart Failure: A Systematic Review and Meta-Analysises_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-NoComercial 4.0 Internacional*
dc.identifier.pubmedID30571603es_ES
dc.format.volume7es_ES
dc.format.number23es_ES
dc.format.pagee008251es_ES
dc.identifier.doi10.1161/JAHA.117.008251es_ES
dc.contributor.funderMinisterio de Educación y Ciencia (España) 
dc.contributor.funderGovernment of Catalonia (España) 
dc.contributor.funderFundación La Marató TV3 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderUniversity of Technology Sydney (Australia) 
dc.contributor.funderChinese University of Hong Kong (China) 
dc.contributor.funderRETICS-Terapia Celular (TERCEL-ISCIII) (España) 
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.description.peerreviewedes_ES
dc.identifier.e-issn2047-9980es_ES
dc.relation.publisherversionhttps://doi.org/10.1161/jaha.117.008251es_ES
dc.identifier.journalJournal of the American Heart Associationes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2014-59892es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0011/0006es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CB16/11/00403es_ES
dc.rights.accessRightsopen accesses_ES


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