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dc.contributor.authorAguero, Jaume 
dc.contributor.authorGalan-Arriola, Carlos 
dc.contributor.authorFernandez-Jimenez, Rodrigo 
dc.contributor.authorSanchez-Gonzalez, Javier 
dc.contributor.authorAjmone, Nina
dc.contributor.authorDelgado, Victoria
dc.contributor.authorSolis, Jorge 
dc.contributor.authorLopez-Martin, Gonzalo J. 
dc.contributor.authorMolina-Iracheta, Antonio 
dc.contributor.authorHajjar, Roger J
dc.contributor.authorBax, Jeroen J
dc.contributor.authorFuster, Valentin 
dc.contributor.authorIbanez, Borja
dc.identifier.citationJ Am Coll Cardiol. 2017; 70(23):2878-2889es_ES
dc.description.abstractBACKGROUND: Left atrial (LA) remodeling after an acute myocardial infarction (MI) is poorly characterized regarding its determinants or its effect on ischemic mitral regurgitation (MR) development. OBJECTIVES: The purpose of this study was: 1) to compare LA structural remodeling in experimental MI swine models recapitulating the effects of left ventricular (LV) dysfunction, ischemic MR, and left atrial infarction (LAI); and 2) to analyze how LA remodeling influences ischemic MR development. METHODS: Three models of MI were generated: 1) proximal left circumflex (LCx) coronary artery occlusion involving the LA branch (LAI group); 2) proximal LCx occlusion not involving the LA branch (LCx group); and 3) left anterior descending (LAD) occlusion (LAD group). Serial cardiac magnetic resonance scans were performed to define LA and LV remodeling and ischemic MR, and were correlated with histology. RESULTS: Occlusion of the LA branch (LAI group) induced a greater degree of LA dilation at 1 and 8 weeks post-MI than the LCx and LAD groups, along with early and severe impairment of LA function. In the LCx and LAD groups, LA dysfunction was less pronounced and not consistent. Development of ischemic MR was more pronounced in the LAI group than in the LCx group. Histology confirmed atrial infarction with extensive fibrosis in the LAI group and interstitial fibrosis in the LCx group. In the LAD group, LA remodeling was not observed by cardiac magnetic resonance or histology. CONCLUSIONS: We provide the first experimental evidence of the deleterious effect of acute LAI on atrial structural remodeling, characterized by early LA dilation, dysfunction, and fibrosis, and early occurrence of ischemic MR.es_ES
dc.description.sponsorshipThis study was supported by a competitive grant from the Carlos III Institute of Health-Fondo de Investigacion Sanitaria and the European Regional Development Fund (ERDF/FEDER) (PI13/01979 and PI16/02110); the Spanish Ministry of Economy, Industry, and Competitiveness (MEIC) and ERDF/FEDER (SAF2013-49663-EXP); and, in part, by the FP7-PEOPLE-2013-ITN Next Generation Training in Cardiovascular Research and Innovation (CARDIONEXT). This research program is part of an institutional agreement between FIIIS-Fundación Jiménez Díaz and the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC). This study forms part of a Master Research Agreement between the CNIC and Philips Healthcare. The CNIC is supported by the MEIC and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MEIC award SEV-2015-0505). The Cardiology Department at Leiden University Medical Center has received unrestricted research grants from Medtronic, Biotronik, Boston Scientific, Edwards Lifesciences, and General Electric Healthcare. Dr. Aguero is an FP7-PEOPLE-2013-ITN-Cardionext fellow. Dr. Fernández-Jiménez holds an FICNIC fellowship from the Fundació Jesús Serra, the Fundación Interhospitalaria de Investigación Cardiovascular (FIC), and CNIC. Dr. Sanchez-Gonzalez is an employee of Philips Healthcare. Dr. Delgado has received speaker fees from Abbott Vascular.es_ES
dc.publisherElsevier es_ES
dc.subjectAtrial fibrosises_ES
dc.subjectAtrial infarctiones_ES
dc.subjectExperimental modeles_ES
dc.subjectMitral regurgitationes_ES
dc.subjectMyocardial infarctiones_ES
dc.subject.meshAnimals es_ES
dc.subject.meshDisease Models, Animal es_ES
dc.subject.meshMale es_ES
dc.subject.meshMitral Valve Insufficiency es_ES
dc.subject.meshMyocardial Infarction es_ES
dc.subject.meshSwine es_ES
dc.subject.meshAtrial Remodeling es_ES
dc.subject.meshHeart Atria es_ES
dc.titleAtrial Infarction and Ischemic Mitral Regurgitation Contribute to Post-MI Remodeling of the Left Atriumes_ES
dc.typejournal articlees_ES
dc.rights.licenseAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderInstituto de Investigación Sanitaria de la Fundación Jiménez Díaz 
dc.contributor.funderPhilips Healthcare
dc.contributor.funderFundación Jesús Serra 
dc.contributor.funderFundación Interhospitalaria de Investigación Cardiovascular 
dc.identifier.journalJournal of the American College of Cardiologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Laboratorio Traslacional para la Imagen y Terapia Cardiovasculares_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen Cardiovascular y Estudios Poblacionaleses_ES
dc.repisalud.orgCNICCNIC::Unidades técnicas::Medicina Comparativaes_ES
dc.rights.accessRightsopen accesses_ES

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Attribution-NonCommercial-NoDerivatives 4.0 Internacional
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