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dc.contributor.authorGómez de Cedrón, Marta
dc.contributor.authorAcin-Perez, Rebeca 
dc.contributor.authorSánchez-Martínez, Ruth
dc.contributor.authorMolina, Susana
dc.contributor.authorHerranz, Jesús
dc.contributor.authorFeliu, Jaime
dc.contributor.authorReglero, Guillermo
dc.contributor.authorEnriquez, José Antonio 
dc.contributor.authorRamírez de Molina, Ana
dc.date.accessioned2019-02-22T14:26:16Z
dc.date.available2019-02-22T14:26:16Z
dc.date.issued2017
dc.identifier.citationMol Oncol. 2017; 11(12):1768-1787es_ES
dc.identifier.issn1574-7891es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7221
dc.description.abstractCancer cell survival and metastasis are dependent on metabolic reprogramming that is capable of increasing resistance to oxidative and energetic stress. Targeting these two processes can be crucial for cancer progression. Herein, we describe the role of microRNA-661 (miR661) as epigenetic regulator of colon cancer (CC) cell metabolism. MicroR661 induces a global increase in reactive oxygen species, specifically in mitochondrial superoxide anions, which appears to be mediated by decreased carbohydrate metabolism and pentose phosphate pathway, and by a higher dependency on mitochondrial respiration. MicroR661 overexpression in non-metastatic human CC cells induces an epithelial-to-mesenchymal transition phenotype, and a reduced tolerance to metabolic stress. This seems to be a general effect of miR661 in CC, since metastatic CC cell metabolism is also compromised upon miR661 overexpression. We propose hexose-6-phosphate dehydrogenase and pyruvate kinase M2 as two key players related to the observed metabolic reprogramming. Finally, the clinical relevance of miR661 expression levels in stage-II and III CC patients is discussed. In conclusion, we propose miR661 as a potential modulator of redox and metabolic homeostasis in CC.es_ES
dc.description.sponsorshipThis work was supported by Ministerio de Econom ıa y Competitividad del Gobierno de España (MINECO/FEDER Plan Nacional I+D+i AGL201348943-C2 and AGL2016-76736-C3-3-R), Gobierno regional de la Comunidad de Madrid (P2013/ABI2728, ALIBIRD-CM) and EU Structural Funds.es_ES
dc.language.isoenges_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectbioenergeticses_ES
dc.subjectcolon canceres_ES
dc.subjectmetabolomicses_ES
dc.subjectmiRes_ES
dc.subjectoxidative stresses_ES
dc.subject.meshCell Line, Tumor es_ES
dc.subject.meshColonic Neoplasms es_ES
dc.subject.meshEpithelial-Mesenchymal Transition es_ES
dc.subject.meshHEK293 Cells es_ES
dc.subject.meshHomeostasis es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMicroRNAs es_ES
dc.subject.meshMitochondria es_ES
dc.subject.meshOxidation-Reduction es_ES
dc.subject.meshOxygen Consumption es_ES
dc.subject.meshPentose Phosphate Pathway es_ES
dc.subject.meshReactive Oxygen Species es_ES
dc.subject.meshEnergy Metabolism es_ES
dc.subject.meshOxidative Stress es_ES
dc.titleMicroRNA-661 modulates redox and metabolic homeostasis in colon canceres_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID28981199es_ES
dc.format.volume11es_ES
dc.format.number12es_ES
dc.format.page1768-1787es_ES
dc.identifier.doi10.1002/1878-0261.12142es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)es_ES
dc.contributor.funderComunidad de Madrides_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1878-0261es_ES
dc.identifier.journalMolecular oncologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativaes_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AGL2013-48943-C2es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/AGL2016-76736-C3-3-Res_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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