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dc.contributor.authorCortegano, Isabel 
dc.contributor.authorMartinez-Carrascoso, Isabel 
dc.contributor.authorPrado-Zamora, Maria Carmen 
dc.contributor.authorRuíz, Carolina 
dc.contributor.authorHortigüela, Rafael 
dc.contributor.authorAlia, Mario 
dc.contributor.authorVilar, Marçal 
dc.contributor.authorMira, Helena
dc.contributor.authorCano, Eva 
dc.contributor.authorDominguez-Rodriguez, Mercedes 
dc.contributor.authorAndres, Belen de 
dc.contributor.authorGaspar, Maria Luisa 
dc.date.accessioned2019-02-20T10:37:10Z
dc.date.available2019-02-20T10:37:10Z
dc.date.issued2017-08-17
dc.identifier.citationCell Death Dis. 2017 Aug 17;8(8):e3000.es_ES
dc.identifier.issn2041-4889es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7189
dc.description.abstractAging has a strong impact on the activity of the immune system, enhancing susceptibility to pathogens and provoking a predominant pre-inflammatory status, whereas dampening responses to vaccines in humans and mice. Here, we demonstrate a loss of marginal zone B lymphocytes (MZ, CD19+CD45R+CD21++CD23lo) and a decrease of naive B cells (CD19+IgD+), whereas there is an enhancement of a CD19+CD45Rlo innate-like B cell population (B1REL) and the so-called aged B cell compartment (ABC, CD45R+CD21loCD23loCD5-CD11b-) in aged senescence-accelerated (SAMP8) mice but not in aged senescence-resistant (SAMR1) mice. These changes in aged SAMP8 mice were associated with lower IgG isotype levels, displaying low variable gene usage repertoires of the immunoglobulin heavy chain (VH) diversity, with a diminution on IgG1-memory B cells (CD11b-Gr1-CD138-IgM-IgD-CD19+CD38+IgG1+), an increase in T follicular helper (TFH, CD4+CXCR5+PD1+) cell numbers, and an altered MOMA-1 (metallophilic macrophages) band in primary follicles. LPS-mediated IgG1 responses were impaired in the B1REL and ABC cell compartments, both in vitro and in vivo. These data demonstrate the prominent changes to different B cell populations and in structural follicle organization that occur upon aging in SAMP8 mice. These novel results raise new questions regarding the importance of the cellular distribution in the B cell layers, and their effector functions needed to mount a coordinated and effective humoral response.es_ES
dc.description.sponsorshipThis work was supported by Acción Estratégica de Salud Carlos III (AESI), Grant PI14/0049 and Ministerio de Economía, Industria y Competitividad (MINECO), Grant SAF2015-70880-R, Grant SAF2015-70433-R and BFU 2013-42746.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Group es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAging es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshAntigens, CD es_ES
dc.subject.meshB-Lymphocytes es_ES
dc.subject.meshCell Death es_ES
dc.subject.meshCell Proliferation es_ES
dc.subject.meshGene Expression Regulation, Developmental es_ES
dc.subject.meshIgG Deficiency es_ES
dc.subject.meshImmunity, Humoral es_ES
dc.subject.meshImmunity, Innate es_ES
dc.subject.meshImmunoglobulin D es_ES
dc.subject.meshImmunoglobulin A es_ES
dc.subject.meshImmunoglobulin Heavy Chains es_ES
dc.subject.meshImmunoglobulin M es_ES
dc.subject.meshImmunologic Memory es_ES
dc.subject.meshLipopolysaccharides es_ES
dc.subject.meshMice, Inbred BALB es_ES
dc.subject.meshMice, Transgenic es_ES
dc.subject.meshPrimary Cell Culture es_ES
dc.subject.meshSignal Transduction es_ES
dc.subject.meshSpleen es_ES
dc.subject.meshT-Lymphocytes, Helper-Inducer es_ES
dc.titleAltered marginal zone and innate-like B cells in aged senescence-accelerated SAMP8 mice with defective IgG1 responseses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID28817118es_ES
dc.format.volume8es_ES
dc.format.number8es_ES
dc.format.pagee3000es_ES
dc.identifier.doi10.1038/cddis.2017.351es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1038/cddis.2017.351es_ES
dc.identifier.journalCell death & diseasees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.centroISCIII::Unidad Funcional de Investigación de Enfermedades Crónicas (UFIEC)es_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/0049es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-70880-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-70433-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU 2013-42746es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
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