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dc.contributor.authorDíaz, Luis Adrian
dc.contributor.authorAlbrieu Llinás, Guillermo
dc.contributor.authorVazquez, Ana 
dc.contributor.authorTenorio, Antonio 
dc.contributor.authorContigiani, Marta Silvia
dc.identifier.citationPLoS Negl Trop Dis. 2012 Jan;6(1):e1489es_ES
dc.description.abstractSt. Louis encephalitis virus is a complex zoonoses. In 2005, 47 laboratory-confirmed and probable clinical cases of SLEV infection were reported in Córdoba, Argentina. Although the causes of 2005 outbreak remain unknown, they might be related not only to virological factors, but also to ecological and environmental conditions. We hypothesized that one of the factors for SLE reemergence in Córdoba, Argentina, was the introduction of a new SLEV genotype (SLEV genotype III), with no previous activity in the area. In order to evaluate this hypothesis we carried out a molecular characterization of SLEV detections from mosquitoes collected between 2001 and 2004 in Córdoba city. A total of 315 mosquito pools (11,002 individuals) including 12 mosquitoes species were analyzed. Overall, 20 pools (8 mosquitoes species) were positive for SLEV. During this study, genotypes II, V and VII were detected. No mosquito pool infected with genotype III was detected before the 2005 outbreak. Genotype V was found every year and in the 8 sampled sites. Genotypes II and VII showed limited temporal and spatial activities. We cannot dismiss the association of genotype II and V as etiological agents during the outbreak. However, the silent circulation of other SLEV strains in Córdoba city before the 2005 outbreak suggests that the introduction of genotype III was an important factor associated to this event. Not mutually exclusive, other factors such as changes in avian hosts and mosquitoes vectors communities, driven by climatic and environmental modifications, should also be taken into consideration in further studies.es_ES
dc.description.sponsorshipThis study was supported by grants from FONCYT-PICT 38060 (Fondo Nacional de Ciencia y Técnica – Ministerio de Ciencia y Tecnología de Argentina), CONICET PIP No: 11220090100882 (Consejo Nacional de Investigaciones Científicas y Técnicas), Agencia Córdoba Ciencia: 0279-005490/2006. Resol. 1210/2007, SECYT-UNC (Secretaría de Ciencia y Técnica – Universidad Nacional de Córdoba) and from ISCIII PI07/1308 (Instituto de Salud Carlos III), RD06/0021 (RICET–Red de Investigación Cooperativa en Enfermedades Tropicales) and DGSP/ISCIII (Dirección General de Salud Pública del Ministerio de Sanidad, Política Social e Igualdad, Spain), with the technical collaboration of the RIVE – CYTED laboratories (Red Iberoamericana de Virosis Emergentes). L.A.D. is an assistant research investigator with CONICET, Argentina. G.A.L. is a recipient of a postdoctoral scholarship from CONICET, Argentina. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAnimals es_ES
dc.subject.meshArgentina es_ES
dc.subject.meshCluster Analysis es_ES
dc.subject.meshCulicidae es_ES
dc.subject.meshEncephalitis Virus, St. Louis es_ES
dc.subject.meshEncephalitis, St. Louis es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMolecular Epidemiology es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshRNA, Viral es_ES
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction es_ES
dc.subject.meshSequence Analysis, DNA es_ES
dc.subject.meshDisease Outbreaks es_ES
dc.titleSilent circulation of St. Louis encephalitis virus prior to an encephalitis outbreak in Cordoba, Argentina (2005)es_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Ciencia y Tecnología (Argentina)es_ES
dc.contributor.funderCONICET: Consejo Nacional de Investigaciones Científicas y Técnicases_ES
dc.contributor.funderUniversidad Nacional de Córdoba (Argentina)es_ES
dc.contributor.funderInstituto de Salud Carlos III-ISCIIIes_ES
dc.identifier.journalPLoS neglected tropical diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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Atribución 4.0 Internacional
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