Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/7156
Early prognostic value of an Algorithm based on spectral Variables of Ventricular fibrillAtion from the EKG of patients with suddEn cardiac death: A multicentre observational study (AWAKE)
Palacios-Rubio, Julián | Marina-Breysse, Manuel CNIC | Quintanilla, Jorge G. CNIC | Gil-Perdomo, José Miguel | Juárez-Fernández, Miriam | Garcia-Gonzalez, Inés | Rial-Bastón, Verónica | Corcobado, María Carmen | Espinosa, María Carmen | Ruiz, Francisco | Gómez-Mascaraque Pérez, Francisco | Bringas-Bollada, María | Lillo-Castellano, Jose Maria CNIC | Pérez-Castellano, Nicasio | Martínez-Sellés, Manuel | López de Sá, Esteban | Martín-Benítez, Juan Carlos | Pérez-Villacastín, Julián | Filgueiras-Rama, David CNIC
Arch Cardiol Mex. 2018; 88(5):460-467
OBJECTIVE: Ventricular fibrillation (VF)-related sudden cardiac death (SCD) is a leading cause of mortality and morbidity. Current biological and imaging parameters show significant limitations on predicting cerebral performance at hospital admission. The AWAKE study (NCT03248557) is a multicentre observational study to validate a model based on spectral ECG analysis to early predict cerebral performance and survival in resuscitated comatose survivors. METHODS: Data from VF ECG tracings of patients resuscitated from SCD will be collected using an electronic Case Report Form. Patients can be either comatose (Glasgow Coma Scale - GCS - ≤8) survivors undergoing temperature control after return of spontaneous circulation (RoSC), or those who regain consciousness (GCS=15) after RoSC; all admitted to Intensive Cardiac Care Units in 4 major university hospitals. VF tracings prior to the first direct current shock will be digitized and analyzed to derive spectral data and feed a predictive model to estimate favorable neurological performance (FNP). The results of the model will be compared to the actual prognosis. RESULTS: The primary clinical outcome is FNP during hospitalization. Patients will be categorized into 4 subsets of neurological prognosis according to the risk score obtained from the predictive model. The secondary clinical outcomes are survival to hospital discharge, and FNP and survival after 6 months of follow-up. The model-derived categorisation will be also compared with clinical variables to assess model sensitivity, specificity, and accuracy. CONCLUSIONS: A model based on spectral analysis of VF tracings is a promising tool to obtain early prognostic data after SCD.
Análisis de onda | Coma | España | Fibrilación ventricular | Muerte súbita | Prognosis | Pronóstico | Reanimación | Resuscitation | Spain | Sudden cardiac death | Ventricular fibrillation | Wavelet analysis
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