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dc.contributor.authorIvanovitch, Kenzo 
dc.contributor.authorTermino, Susana 
dc.contributor.authorTorres, Miguel 
dc.date.accessioned2019-02-07T14:44:34Z
dc.date.available2019-02-07T14:44:34Z
dc.date.issued2017
dc.identifier.citationElife. 2017; 6:e30668es_ES
dc.identifier.issn2050-084Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7147
dc.description.abstractDuring vertebrate heart development, two progenitor populations, first and second heart fields (FHF, SHF), sequentially contribute to longitudinal subdivisions of the heart tube (HT), with the FHF contributing the left ventricle and part of the atria, and the SHF the rest of the heart. Here, we study the dynamics of cardiac differentiation and morphogenesis by tracking individual cells in live analysis of mouse embryos. We report that during an initial phase, FHF precursors differentiate rapidly to form a cardiac crescent, while limited morphogenesis takes place. In a second phase, no differentiation occurs while extensive morphogenesis, including splanchnic mesoderm sliding over the endoderm, results in HT formation. In a third phase, cardiac precursor differentiation resumes and contributes to SHF-derived regions and the dorsal closure of the HT. These results reveal tissue-level coordination between morphogenesis and differentiation during HT formation and provide a new framework to understand heart development.es_ES
dc.language.isoenges_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectcardiac crescentes_ES
dc.subjectcardiac developmentes_ES
dc.subjectdevelopmental biologyes_ES
dc.subjectfirst heart fieldes_ES
dc.subjectheart tubees_ES
dc.subjectlive-imaginges_ES
dc.subjectmousees_ES
dc.subjectsecond heart fieldes_ES
dc.subjectstem cellses_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCell Differentiation es_ES
dc.subject.meshHeart es_ES
dc.subject.meshMice es_ES
dc.subject.meshSpatio-Temporal Analysis es_ES
dc.subject.meshIntravital Microscopy es_ES
dc.subject.meshMorphogenesis es_ES
dc.titleLive imaging of heart tube development in mouse reveals alternating phases of cardiac differentiation and morphogenesises_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29202929es_ES
dc.format.volume6es_ES
dc.identifier.doi10.7554/eLife.30668es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderEuropean Molecular Biology Organization (EMBO)es_ES
dc.contributor.funderHuman Frontier Science Program (HFSP)es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn2050-084Xes_ES
dc.relation.publisherversionhttps://doi.org/10.7554/eLife.30668es_ES
dc.identifier.journaleLifees_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Control Genético del Desarrollo y Regeneración de Órganoses_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2015-71519-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU2015-70193-REDTes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RD16/0011/0019es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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Atribución 4.0 Internacional
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