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dc.contributor.authorHerrero-Galan, Elas 
dc.contributor.authorMartinez-Martin, Ines 
dc.contributor.authorAlegre-Cebollada, Jorge 
dc.date.accessioned2019-02-06T08:29:08Z
dc.date.available2019-02-06T08:29:08Z
dc.date.issued2018-12-12
dc.identifier.citationRedox Biol. 2018; 21:101074es_ES
dc.identifier.issn22132317es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7127
dc.description.abstractThe nanomechanics of sarcomeric proteins is a key contributor to the mechanical output of muscle. Among them, titin emerges as a main target for the regulation of the stiffness of striated muscle. In the last years, single-molecule experiments by Atomic Force Microscopy (AFM) have demonstrated that redox posttranslational modifications are strong modulators of the mechanical function of titin. Here, we provide an overview of the recent development of the redox mechanobiology of titin, and suggest avenues of research to better understand how the stiffness of molecules, cells and tissues are modulated by redox signaling in health and disease.es_ES
dc.description.sponsorshipWe acknowledge funding from the Ministerio de Ciencia, Innovación y Universidades (MCNU) through grants BIO2017-83640-P (AEI/FEDER, UE) and RYC-2014-16604, the European Research Area Network on Cardiovascular Diseases (ERA-CVD/ISCIII, MINOTAUR, AC16/00045), and the CNIC-Severo Ochoa intramural grant program (03-2016 IGP). The CNIC is supported by the MCNU and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV-20150505). IMM is recipient of a CNIC-ACCIONA Master Fellowshipes_ES
dc.language.isoenges_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleRedox regulation of protein nanomechanics in health and disease: Lessons from titines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30584979es_ES
dc.format.volume21es_ES
dc.format.page101074es_ES
dc.identifier.doi10.1016/j.redox.2018.101074es_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España) 
dc.contributor.funderEuropean Research Area Network on Cardiovascular Diseases 
dc.contributor.funderFundación ProCNIC 
dc.description.peerreviewedes_ES
dc.identifier.e-issn2213-2317es_ES
dc.identifier.journalRedox biologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Mecánica molecular del sistema cardiovasculares_ES
dc.repisalud.institucionCNICes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BIO2017-83640-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/RYC-2014-16604es_ES
dc.rights.accessRightsopen accesses_ES


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