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dc.contributor.authorGarrido-Estepa, Macarena 
dc.contributor.authorRuiz-Perales, Francisco
dc.contributor.authorMiranda, Josefa
dc.contributor.authorAscunce, Nieves
dc.contributor.authorGonzález-Román, Isabel
dc.contributor.authorSánchez-Contador, Carmen
dc.contributor.authorSantamariña, Carmen
dc.contributor.authorMoreo, Pilar
dc.contributor.authorVidal, Carmen
dc.contributor.authorPeris, Mercé
dc.contributor.authorMoreno, María P
dc.contributor.authorVáquez-Carrete, Jose A
dc.contributor.authorCollado-García, Francisca
dc.contributor.authorCasanova, Francisco
dc.contributor.authorEderra, María
dc.contributor.authorSalas, Dolores
dc.contributor.authorPollan-Santamaria, Marina 
dc.date.accessioned2019-02-05T11:24:09Z
dc.date.available2019-02-05T11:24:09Z
dc.date.issued2010-09-13
dc.identifier.citationBMC Cancer. 2010 Sep 13;10:485.es_ES
dc.identifier.issn1471-2407es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7107
dc.description.abstractBACKGROUND: Increased mammographic breast density is a moderate risk factor for breast cancer. Different scales have been proposed for classifying mammographic density. This study sought to assess intra-rater agreement for the most widely used scales (Wolfe, Tabár, BI-RADS and Boyd) and compare them in terms of classifying mammograms as high- or low-density. METHODS: The study covered 3572 mammograms drawn from women included in the DDM-Spain study, carried-out in seven Spanish Autonomous Regions. Each mammogram was read by an expert radiologist and classified using the Wolfe, Tabár, BI-RADS and Boyd scales. In addition, 375 mammograms randomly selected were read a second time to estimate intra-rater agreement for each scale using the kappa statistic. Owing to the ordinal nature of the scales, weighted kappa was computed. The entire set of mammograms (3572) was used to calculate agreement among the different scales in classifying high/low-density patterns, with the kappa statistic being computed on a pair-wise basis. High density was defined as follows: percentage of dense tissue greater than 50% for the Boyd, "heterogeneously dense and extremely dense" categories for the BI-RADS, categories P2 and DY for the Wolfe, and categories IV and V for the Tabár scales. RESULTS: There was good agreement between the first and second reading, with weighted kappa values of 0.84 for Wolfe, 0.71 for Tabár, 0.90 for BI-RADS, and 0.92 for Boyd scale. Furthermore, there was substantial agreement among the different scales in classifying high- versus low-density patterns. Agreement was almost perfect between the quantitative scales, Boyd and BI-RADS, and good for those based on the observed pattern, i.e., Tabár and Wolfe (kappa 0.81). Agreement was lower when comparing a pattern-based (Wolfe or Tabár) versus a quantitative-based (BI-RADS or Boyd) scale. Moreover, the Wolfe and Tabár scales classified more mammograms in the high-risk group, 46.61 and 37.32% respectively, while this percentage was lower for the quantitative scales (21.89% for BI-RADS and 21.86% for Boyd). CONCLUSIONS: Visual scales of mammographic density show a high reproducibility when appropriate training is provided. Their ability to distinguish between high and low risk render them useful for routine use by breast cancer screening programs. Quantitative-based scales are more specific than pattern-based scales in classifying populations in the high-risk group.es_ES
dc.description.sponsorshipThis study was supported by research grant FIS PI060386 from Fondo de Investigación Sanitaria, Spain and by collaboration agreement EPY 1306/06 between Astra-Zeneca and the Carlos III Institute of Health.es_ES
dc.language.isoenges_ES
dc.publisherBioMed Central (BMC) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshBreast Neoplasms es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshObserver Variation es_ES
dc.subject.meshPrognosis es_ES
dc.subject.meshReproducibility of Results es_ES
dc.subject.meshMammography es_ES
dc.subject.meshWeights and Measures es_ES
dc.titleEvaluation of mammographic density patterns: reproducibility and concordance among scaleses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID20836850es_ES
dc.format.volume10es_ES
dc.format.number1es_ES
dc.format.page485es_ES
dc.identifier.doi10.1186/1471-2407-10-485es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.1186/1471-2407-10-485es_ES
dc.identifier.journalBMC canceres_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI060386es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/EPY 1306/06es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional