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dc.contributor.authorAvellón, Ana 
dc.contributor.authorCasas Flecha, Inmaculada 
dc.contributor.authorTrallero, Gloria 
dc.contributor.authorPérez, Carmen
dc.contributor.authorTenorio, Antonio 
dc.contributor.authorPalacios, Gustavo
dc.date.accessioned2019-02-01T17:39:32Z
dc.date.available2019-02-01T17:39:32Z
dc.date.issued2003-08
dc.identifier.citationEmerg Infect Dis. 2003;9(8):934-41.es_ES
dc.identifier.issn1080-6040es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/7071
dc.description.abstractEchovirus 13 (EV13), considered rare, was reported worldwide in 2000, mostly related to aseptic meningitis outbreaks. In Spain, 135 EV13 isolates were identified. The genetic relationships between 64 representative strains from Spain and other reported isolates from the United States, Germany, Italy, Japan, and Sweden were described by analyzing the partial sequence of the major capsid protein (VP1) gene. The strains from Spain were clearly identified as EV13 (79.5% similarity with the EV13 reference strain) and were grouped phylogenetically into two different clusters (by origination on either the Iberian Peninsula or Canary Islands). Isolates from Germany from 2000 clustered with the Canary Islands group. The isolates from other countries obtained before 2000 were genetically distant. Changes in EV13 coding sequence involved several differences in the C-terminal extreme of the VP1 protein. Part of the neutralizing antigenic site III has been described in this genome region in poliovirus and swine vesicular disease virus.es_ES
dc.description.sponsorshipThe work was supported by the MPY1197/02 grant from the Instituto de Salud Carlos III (Spanish Ministry of Health) and in part by NIH grants NS29425 and AI51202.es_ES
dc.language.isoenges_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAmino Acid Sequence es_ES
dc.subject.meshEchovirus Infections es_ES
dc.subject.meshEnterovirus B, Human es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMeningitis, Aseptic es_ES
dc.subject.meshOligonucleotide Array Sequence Analysis es_ES
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction es_ES
dc.subject.meshSpain es_ES
dc.titleMolecular analysis of echovirus 13 isolates and aseptic meningitis, Spaines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución-4.0 Internacional*
dc.identifier.pubmedID12967490es_ES
dc.format.volume9es_ES
dc.format.number8es_ES
dc.format.page934-41es_ES
dc.identifier.doi10.3201/eid0908.030080es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderNational Institutes of Health (Estados Unidos) 
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://doi.org/10.3201/eid0908.030080es_ES
dc.identifier.journalEmerging infectious diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MPY1197/02es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución-4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución-4.0 Internacional