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dc.contributor.author | de la Campa, Adela G | |
dc.contributor.author | Ardanuy, Carmen | |
dc.contributor.author | Balsalobre-Arenas, Maria Luz | |
dc.contributor.author | Pérez-Trallero, Emilio | |
dc.contributor.author | Marimón, Jose M | |
dc.contributor.author | Fenoll, Asuncion | |
dc.contributor.author | Liñares, Josefina | |
dc.date.accessioned | 2019-02-01T15:58:28Z | |
dc.date.available | 2019-02-01T15:58:28Z | |
dc.date.issued | 2009-06 | |
dc.identifier.citation | Emerg Infect Dis. 2009;15(6):905-11. | es_ES |
dc.identifier.issn | 1080-6040 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/7068 | |
dc.description.abstract | Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance remained stable. Low-level resistance (30 isolates with MIC 4-8 microg/mL) was caused by a reserpine-sensitive efflux phenotype (n = 4) or single topoisomerase IV (parC [n = 24] or parE [n = 1]) changes. One isolate did not show reserpine-sensitive efflux or mutations. High-level resistance (68 isolates with MIC >or=16 microg/mL) was caused by changes in gyrase (gyrA) and parC or parE. New changes in parC (S80P) and gyrA (S81V, E85G) were shown to be involved in resistance by genetic transformation. Although 49 genotypes were observed, clones Spain9V-ST156 and Sweden15A-ST63 accounted for 34.7% of drug-resistant isolates. In comparison with findings from the 2002 study, clones Spain14-ST17, Spain23F-ST81, and ST8819F decreased and 4 new genotypes (ST9710A, ST57016, ST43322, and ST71733) appeared in 2006. | es_ES |
dc.description.sponsorship | This study was supported by grant BIO2008-02154 from Plan Nacional de I+D+I of Ministerio de Ciencia e Innovación and COMBACT-S-BIO-0260/2006 from Comunidad de Madrid | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Centers for Disease Control and Prevention (CDC) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Anti-Bacterial Agents | es_ES |
dc.subject.mesh | Bacterial Proteins | es_ES |
dc.subject.mesh | Child | es_ES |
dc.subject.mesh | Child, Preschool | es_ES |
dc.subject.mesh | Ciprofloxacin | es_ES |
dc.subject.mesh | Drug Resistance, Bacterial | es_ES |
dc.subject.mesh | Electrophoresis, Gel, Pulsed-Field | es_ES |
dc.subject.mesh | Fluoroquinolones | es_ES |
dc.subject.mesh | Genotype | es_ES |
dc.subject.mesh | Heptavalent Pneumococcal Conjugate Vaccine | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Microbial Sensitivity Tests | es_ES |
dc.subject.mesh | Mutation | es_ES |
dc.subject.mesh | Pneumococcal Vaccines | es_ES |
dc.subject.mesh | Prevalence | es_ES |
dc.subject.mesh | Sequence Analysis, DNA | es_ES |
dc.subject.mesh | Serotyping | es_ES |
dc.subject.mesh | Spain | es_ES |
dc.subject.mesh | Streptococcal Infections | es_ES |
dc.subject.mesh | Streptococcus pneumoniae | es_ES |
dc.subject.mesh | Transformation, Bacterial | es_ES |
dc.subject.mesh | Vaccination | es_ES |
dc.title | Changes in fluoroquinolone-resistant Streptococcus pneumoniae after 7-valent conjugate vaccination, Spain | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución- 4.0 Internacional | * |
dc.identifier.pubmedID | 19523289 | es_ES |
dc.format.volume | 15 | es_ES |
dc.format.number | 6 | es_ES |
dc.format.page | 905-11 | es_ES |
dc.identifier.doi | 10.3201/eid1506.080684 | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1080-6059 | es_ES |
dc.relation.publisherversion | https://www.doi.org/10.3201/eid1506.080684 | es_ES |
dc.identifier.journal | Emerging infectious diseases | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/BIO2008-02154 | es_ES |
dc.rights.accessRights | open access | es_ES |