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dc.contributor.authorBello, Gonzalo
dc.contributor.authorAulicino, Paula C
dc.contributor.authorRuchansky, Dora
dc.contributor.authorGuimarães, Monick L
dc.contributor.authorLopez-Galindez, Luis Cecilio 
dc.contributor.authorCasado, Concepcion 
dc.contributor.authorChiparelli, Hector
dc.contributor.authorRocco, Carlos
dc.contributor.authorMangano, Andrea
dc.contributor.authorSen, Luisa
dc.contributor.authorMorgado, Mariza G
dc.identifier.citationRetrovirology. 2010 Mar 22;7:22.es_ES
dc.description.abstractBACKGROUND: Although HIV-1 CRF12_BF and CRF38_BF are two epidemiologically important recombinant lineages circulating in Argentina and Uruguay, little is known about their population dynamics. METHODS: A total of 120 "CRF12_BF-like" and 20 "CRF38_BF-like" pol recombinant sequences collected in Argentina and Uruguay from 1997 to 2009 were subjected to phylogenetic and Bayesian coalescent-based analyses to estimate evolutionary and demographic parameters. RESULTS: Phylogenetic analyses revealed that CRF12_BF viruses from Argentina and Uruguay constitute a single epidemic with multiple genetic exchanges among countries; whereas circulation of the CRF38_BF seems to be confined to Uruguay. The mean estimated substitution rate of CRF12_BF at pol gene (2.5 x 10-3 substitutions/site/year) was similar to that previously described for subtype B. According to our estimates, CRF12_BF and CRF38_BF originated at 1983 (1978-1988) and 1986 (1981-1990), respectively. After their emergence, the CRF12_BF and CRF38_BF epidemics seem to have experienced a period of rapid expansion with initial growth rates of around 1.2 year-1 and 0.9 year-1, respectively. Later, the rate of spread of these CRFs_BF seems to have slowed down since the mid-1990s. CONCLUSIONS: Our results suggest that CRF12_BF and CRF38_BF viruses were generated during the 1980s, shortly after the estimated introduction of subtype F1 in South America (~1975-1980). After an initial phase of fast exponential expansion, the rate of spread of both CRFs_BF epidemics seems to have slowed down, thereby following a demographic pattern that resembles those previously reported for the HIV-1 epidemics in Brazil, USA, and Western Europe.es_ES
dc.description.sponsorshipThis study was supported by the Brazilian CNPq/PROSUL grant 490585/2007-8. Work in the "Laboratorio de Biología Celular y Retrovirus" was supported by the "Agencia Nacional de Promoción Científica y Tecnológica" Award PICT 2004-25830, and CONICET Award PIP 6057. Work in the "Centro Nacional de Microbiología" was supported by grants SAF 2005/03833 and SAF 2007/61036 of the "Plan Nacional del SIDA", and by the "Red Tematica Cooperativa de Investigación en SIDA (Red de grupos 173)" of the "Fondo de Investigaciones Sanitarias de la Seguridad Social (FISss)". GB was funded by a fellowship from the Brazilian CNPq/FIOCRUZ "Pesquisador Visitante" Program.es_ES
dc.publisherBiomed Centrales_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAdult es_ES
dc.subject.meshArgentina es_ES
dc.subject.meshChild es_ES
dc.subject.meshChild, Preschool es_ES
dc.subject.meshCluster Analysis es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshHIV Infections es_ES
dc.subject.meshHIV-1 es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMolecular Epidemiology es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshPoint Mutation es_ES
dc.subject.meshSequence Analysis, DNA es_ES
dc.subject.meshSequence Homology es_ES
dc.subject.meshUruguay es_ES
dc.subject.meshYoung Adult es_ES
dc.subject.meshpol Gene Products, Human Immunodeficiency Virus es_ES
dc.subject.meshRecombination, Genetices_ES
dc.titlePhylodynamics of HIV-1 circulating recombinant forms 12_BF and 38_BF in Argentina and Uruguayes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderConselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil)es_ES
dc.contributor.funderAgencia Nacional de Promoción Científica y Tecnológica (Argentina)es_ES
dc.contributor.funderFondo de Investigaciones Sanitariases_ES
dc.contributor.funderPlan Nacional de Sida (España)es_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF 2005/03833es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF 2007/61036es_ES

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Atribución 4.0 Internacional
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