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dc.contributor.authorGil, Horacio 
dc.contributor.authorEscudero, Raquel 
dc.contributor.authorPons, Inmaculada
dc.contributor.authorRodriguez-Vargas, Manuela 
dc.contributor.authorGarcia-Esteban, Coral 
dc.contributor.authorRodriguez-Moreno, Isabel 
dc.contributor.authorGarcia-Amil, Cristina 
dc.contributor.authorLobo, Bruno 
dc.contributor.authorValcárcel, Félix
dc.contributor.authorPérez, Azucena
dc.contributor.authorJiménez, Santos
dc.contributor.authorJado, Isabel 
dc.contributor.authorJuste, Ramón
dc.contributor.authorSegura, Ferrán
dc.contributor.authorAnda, Pedro 
dc.date.accessioned2018-12-26T12:22:15Z
dc.date.available2018-12-26T12:22:15Z
dc.date.issued2013-07-09
dc.identifier.citationPLoS One. 2013 Jul 9;8(7):e68248es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6938
dc.description.abstractWe have studied the diversity of B. henselae circulating in patients, reservoir hosts and vectors in Spain. In total, we have fully characterized 53 clinical samples from 46 patients, as well as 78 B. henselae isolates obtained from 35 cats from La Rioja and Catalonia (northeastern Spain), four positive cat blood samples from which no isolates were obtained, and three positive fleas by Multiple Locus Sequence Typing and Multiple Locus Variable Number Tandem Repeats Analysis. This study represents the largest series of human cases characterized with these methods, with 10 different sequence types and 41 MLVA profiles. Two of the sequence types and 35 of the profiles were not described previously. Most of the B. henselae variants belonged to ST5. Also, we have identified a common profile (72) which is well distributed in Spain and was found to persist over time. Indeed, this profile seems to be the origin from which most of the variants identified in this study have been generated. In addition, ST5, ST6 and ST9 were found associated with felines, whereas ST1, ST5 and ST8 were the most frequent sequence types found infecting humans. Interestingly, some of the feline associated variants never found on patients were located in a separate clade, which could represent a group of strains less pathogenic for humans.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Fondo de Investigación Sanitaria (PI10/00051 and PI10/00165). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshBartonella Infections es_ES
dc.subject.meshBartonella henselae es_ES
dc.subject.meshCat-Scratch Disease es_ES
dc.subject.meshCats es_ES
dc.subject.meshCtenocephalides es_ES
dc.subject.meshDisease Reservoirs es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMinisatellite Repeats es_ES
dc.subject.meshMultilocus Sequence Typing es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshPhylogeography es_ES
dc.subject.meshSpain es_ES
dc.subject.meshDisease Vectors es_ES
dc.titleDistribution of Bartonella henselae variants in patients, reservoir hosts and vectors in Spaines_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID23874563es_ES
dc.format.volume8es_ES
dc.format.number7es_ES
dc.format.pagee68248es_ES
dc.identifier.doi10.1371/journal.pone.0068248es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1932-6203es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0068248es_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/00051es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI10/00165es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional