dc.contributor.author | Pernas, Maria | |
dc.contributor.author | Sanchez-Merino, Victor | |
dc.contributor.author | Casado, Concepcion | |
dc.contributor.author | Merino-Mansilla, Alberto | |
dc.contributor.author | Olivares, Isabel | |
dc.contributor.author | Yuste-Herranz, Maria Eloisa | |
dc.contributor.author | Lopez-Galindez, Luis Cecilio | |
dc.date.accessioned | 2018-12-21T11:00:47Z | |
dc.date.available | 2018-12-21T11:00:47Z | |
dc.date.issued | 2015-08-10 | |
dc.identifier.citation | PLoS One. 2015 Aug 10;10(8):e0134054 | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6929 | |
dc.description.abstract | This study evaluated the neutralization breadth in dually infected (DI) HIV-1 long-term non-progressor elite controller patients (LTNP-EC) using a representative minipanel of 6 viruses from 5 different subtypes. Our results showed an improved neutralization breadth in DI LTNP-EC patients when compared with matched LTNP single-infected patients. The role of viral diversity in neutralization was estimated with the Shannon Entropy and the p-distance in viral quasispecies. We found a positive correlation between neutralization breadth and diversity within the viral quasispecies. This correlation could explain why a group of LTNP-EC patients developed a broad neutralizing response despite having undetectable levels of viremia. | es_ES |
dc.description.sponsorship | Work in CNM is supported by grants from Fundacion para la Investigación del Sida en España (www.fipse.es) and (PI 13/02269) Fondo de Investigación Sanitaria (ISCIII) (www.isciii.es) to CL. Red de Investigación en SIDA www.retic-ris.net to CL. A grant RD12/0017/0036 to CL as part of the Plan Nacional R D+I and cofinanced by ISCIII (www.isciii.es) - Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER). CL IDIBAPS work was supported by a grant (RYC-2007-00788) to EY from the Ministerio de Ciencia y Tecnologia www.micinn.es, a grant (PS09/01459) to EY from the Fondo de Investigaciones Sanitarias (ISCIII) (www.isciii.es). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Antibodies, Neutralizing | es_ES |
dc.subject.mesh | Entropy | es_ES |
dc.subject.mesh | Follow-Up Studies | es_ES |
dc.subject.mesh | Genetic Variation | es_ES |
dc.subject.mesh | HIV Antibodies | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | HIV-1 | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Neutralization Tests | es_ES |
dc.subject.mesh | Phylogeny | es_ES |
dc.subject.mesh | Viral Load | es_ES |
dc.subject.mesh | Viremia | es_ES |
dc.subject.mesh | HIV Long-Term Survivors | es_ES |
dc.title | HIV-1 Dual Infected LTNP-EC Patients Developed an Unexpected Antibody Cross-Neutralizing Activity | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 26258485 | es_ES |
dc.format.volume | 10 | es_ES |
dc.format.number | 8 | es_ES |
dc.format.page | e0134054 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0134054 | es_ES |
dc.contributor.funder | Fundación para la Investigación y la Prevención del Sida en España | |
dc.contributor.funder | Red de Investigación Cooperativa en Investigación en Sida (España) | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (España) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1932-6203 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0134054 | es_ES |
dc.identifier.journal | PloS one | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Microbiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI 13/02269 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RD12/0017/0036 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/RYC-2007-00788 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PS09/01459 | es_ES |
dc.rights.accessRights | open access | es_ES |