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dc.contributor.authorRodriguez Martinez, Javier M 
dc.contributor.authorMoreno, Leticia Tais
dc.contributor.authorAlejo, Alí
dc.contributor.authorLacasta, Anna
dc.contributor.authorLopez-Rodriguez, Fernando 
dc.contributor.authorSalas, María L
dc.identifier.citationPLoS One. 2015 Nov 30;10(11):e0142889es_ES
dc.description.abstractThe strain BA71V has played a key role in African swine fever virus (ASFV) research. It was the first genome sequenced, and remains the only genome completely determined. A large part of the studies on the function of ASFV genes, viral transcription, replication, DNA repair and morphogenesis, has been performed using this model. This avirulent strain was obtained by adaptation to grow in Vero cells of the highly virulent BA71 strain. We report here the analysis of the genome sequence of BA71 in comparison with that of BA71V. They possess the smallest genomes for a virulent or an attenuated ASFV, and are essentially identical except for a relatively small number of changes. We discuss the possible contribution of these changes to virulence. Analysis of the BA71 sequence allowed us to identify new similarities among ASFV proteins, and with database proteins including two ASFV proteins that could function as a two-component signaling network.es_ES
dc.description.sponsorshipThis study was supported by grants from the Spanish Ministerio de Economía y Competitividad (AGL2013-43998-C2-1/2-R) and by an institutional grant from Fundación Ramón Areces. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAfrican Swine Fever Virus es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBase Sequence es_ES
dc.subject.meshCells, Cultured es_ES
dc.subject.meshCercopithecus aethiopses_ES
dc.subject.meshMolecular Sequence Data es_ES
dc.subject.meshSwine es_ES
dc.subject.meshVero Cells es_ES
dc.subject.meshVirulence es_ES
dc.subject.meshGenome, Viral es_ES
dc.titleGenome Sequence of African Swine Fever Virus BA71, the Virulent Parental Strain of the Nonpathogenic and Tissue-Culture Adapted BA71Ves_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderFundación Ramón Areceses_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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Atribución 4.0 Internacional
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