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dc.contributor.authorPedro-Cuesta, Jesus de 
dc.contributor.authorMahillo-Fernandez, Ignacio 
dc.contributor.authorCalero, Miguel 
dc.contributor.authorRábano, Alberto
dc.contributor.authorCruz, Mabel
dc.contributor.authorSiden, Åke
dc.contributor.authorMartínez-Martín, Pablo 
dc.contributor.authorLaursen, Henning
dc.contributor.authorRuiz-Tovar, Maria 
dc.contributor.authorMølbak, Kåre
dc.identifier.citationPLoS One. 2014; 9(10):e109412es_ES
dc.description.abstractINTRODUCTION: Sporadic Creutzfeldt-Jakob disease (sCJD) might be transmitted by surgery. The purpose of this study was to investigate potential susceptibility to sCJD from surgery at juvenile age and in early adulthood. METHODS: From Danish and Swedish national registries we identified 167 definite and probable sCJD cases with onset from 1987 through 2003, and 835 age-, sex- and residence-matched controls along with their surgical histories. Main, anatomically or etiologically classified surgical procedures followed by a ≥20-year lag were analyzed using logistic regression, and stratified by age at first-registered surgical discharge. RESULTS: The risk of having a diagnosis of CJD depended strongly on age at first surgery with odds ratio (OR) of 12.80 (95% CI 2.56-64.0) in patients <30 years, 3.04 (95% 1.26-7.33) in 30-39 years, and 1.75 (95% CI 0.89-3.45) in ≥40 years, for anatomically classified surgical procedures. Similar figures were obtained for etiologically classified surgical procedures. CONCLUSIONS: Risk of surgical-acquired sCJD depends on age at exposure; this pattern is similar to age-specific profiles reported for CJD accidentally transmitted by human pituitary-derived growth hormone and susceptibility curves for variant CJD estimated after adjustment for dietary exposure to bovine spongiform encephalopathy. There might be an age-at-exposure-related susceptibility to acquire all CJD forms, including sCJD from routine surgery.es_ES
dc.description.sponsorshipFunding was obtained from the EU Research Commission, Concerted Action QLRG3-CT-2002-81223 NEUROPRION and the Spanish Centro de Investigaciones en enfermedades Neurológicas (CIEN C03-06), and Consortium for Biomedical Research in Neurodegenerative Diseases (CIBERNED) networks, and from the Karolinska and Carlos III National Health Institutes. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAge Factors es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshCreutzfeldt-Jakob Syndrome es_ES
dc.subject.meshData Interpretation, Statistical es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLogistic Models es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshModels, Statistical es_ES
dc.subject.meshRegistries es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshYoung Adult es_ES
dc.titleTowards an age-dependent transmission model of acquired and sporadic Creutzfeldt-Jakob diseasees_ES
dc.typeresearch articlees_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.contributor.funderUnión Europea. Comisión Europea. 6 Programa Marco 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderKarolinska Institutet 
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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