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dc.contributor.authorNicolas-Avila, Jose A. 
dc.contributor.authorHidalgo, Andrés 
dc.contributor.authorBallesteros, Ivan 
dc.date.accessioned2018-12-17T10:49:05Z
dc.date.available2018-12-17T10:49:05Z
dc.date.issued2018-10
dc.identifier.citationJ Leukoc Biol. 2018; 104(4):743-753es_ES
dc.identifier.issn0741-5400es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6863
dc.description.abstractThe functions of macrophages in healthy tissues extend beyond their well-established roles as immune sentinels and effectors. Among tissues, cells of the brain and heart possess unique excitatory properties that likely demand special support. Accordingly, existing evidence demonstrates that microglia in the brain has an active role in synaptic organization, control of neuronal excitability, phagocytic removal of debris, and trophic support during brain development. In the heart, recent studies suggest that cardiac macrophages are involved in the regulation of heart homeostasis by phagocytosis, production of trophic, and immune-related factors, and by forming direct contacts with cardiomyocytes to regulate electrical conduction. In this review, we discuss mechanisms associated with the high degree of specialization of resident macrophages in both tissues, their origin and heterogeneity, and their contributions in regulating homeostasis under steady-state and pathological conditions.es_ES
dc.description.sponsorshipThis work was supported by grants Fundació La Marató de TV3 (120/C/2015-20153032), intramural grant IGP-SO and SAF2015- 65607-RfromtheMinisteriodeCiencia,InnovaciónyUniversidades (MCIU)toA.H.J.A.N-AissupportedbyfellowshipSVP-2014-068595. I.B. is supported by fellowship MSCA-IF-EF-748381. The CNIC is supported by the MCIU and the Pro-CNIC Foundation, and Severo Ochoa Center of Excellence (MCIU award SEV-2015-0505). Illus- trations were created by adapting templates from Servier Medical Arts(http://www.servier.com/Powerpoint-image-bank,licensedunder aCreativeCommonsAttribution3.0License)
dc.language.isoenges_ES
dc.relation.isversionofPostprintes_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/*
dc.subjectbraines_ES
dc.subjectcirculatory/cardiaces_ES
dc.subjectinnate cell mediated immunityes_ES
dc.subjectmonocytes/macrophageses_ES
dc.subjectmyeloid cellses_ES
dc.titleSpecialized functions of resident macrophages in brain and heartes_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-NoComercial-CompartirIgual 4.0 Internacional*
dc.identifier.pubmedID29947422es_ES
dc.format.volume104es_ES
dc.format.number4es_ES
dc.format.page743-756es_ES
dc.identifier.doi10.1002/JLB.6MR0118-041Res_ES
dc.contributor.funderFundacio la Maratoes_ES
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)es_ES
dc.contributor.funderFundación ProCNICes_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1938-3673es_ES
dc.relation.publisherversionhttps://doi.org/10.1002/JLB.6MR0118-041R
dc.identifier.journalJournal of leukocyte biologyes_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmunees_ES
dc.repisalud.institucionCNICes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/embargoedAccesses_ES


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Atribución-NoComercial-CompartirIgual 4.0 Internacional
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