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dc.contributor.authorMartinez-Morales, Patricia L 
dc.contributor.authorListe-Noya, Isabel 
dc.date.accessioned2018-12-13T12:15:04Z
dc.date.available2018-12-13T12:15:04Z
dc.date.issued2012-02
dc.identifier.citationStem Cells Int. 2012;2012:980941.es_ES
dc.identifier.issn1687-966Xes_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6850
dc.description.abstractProgress in understanding neurodegenerative cell biology in Parkinson's disease (PD) has been hampered by a lack of predictive and relevant cellular models. In addition, the lack of an adequate in vitro human neuron cell-based model has been an obstacle for the uncover of new drugs for treating PD. The ability to generate induced pluripotent stem cells (iPSCs) from PD patients and a refined capacity to differentiate these iPSCs into DA neurons, the relevant disease cell type, promises a new paradigm in drug development that positions human disease pathophysiology at the core of preclinical drug discovery. Disease models derived from iPSC that manifest cellular disease phenotypes have been established for several monogenic diseases, but iPSC can likewise be used for phenotype-based drug screens in complex diseases for which the underlying genetic mechanism is unknown. Here, we highlight recent advances as well as limitations in the use of iPSC technology for modelling PD "in a dish" and for testing compounds against human disease phenotypes in vitro. We discuss how iPSCs are being exploited to illuminate disease pathophysiology, identify novel drug targets, and enhance the probability of clinical success of new drugs.es_ES
dc.language.isoenges_ES
dc.publisherHindawi Publishing Corporationes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleStem cells as in vitro model of Parkinson's diseasees_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución-4.0 Internacional*
dc.identifier.pubmedID22619684es_ES
dc.format.volume2012es_ES
dc.format.page980941es_ES
dc.identifier.doi10.1155/2012/980941es_ES
dc.description.peerreviewedes_ES
dc.identifier.e-issn1687-9678es_ES
dc.relation.publisherversionhttps://www.doi.org/10.1155/2012/980941es_ES
dc.identifier.journalStem cells internationales_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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