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dc.contributor.authorGómez-Moreno, Ana Zaida
dc.contributor.authorJimenez-Sousa, Maria Angeles 
dc.contributor.authorSánchez-Ruano, Juan Jose
dc.contributor.authorArtaza-Varasa, Tomas
dc.contributor.authorSaura-Montalbán, José
dc.contributor.authorRyan, Pablo
dc.contributor.authorResino, Salvador 
dc.contributor.authorPineda-Tenor, Daniel
dc.identifier.citationPLoS One. 2017 Sep 7;12(9):e0184404.es_ES
dc.description.abstractThe management of patients with chronic hepatitis C (CHC) depends on their clinical stage. Thus, noninvasive early recognition of patients with CHC at high risk for developing liver-related events (LREs) is important because it ensures optimal preventative management strategies may be employed that can affect the course of CHC disease. Our aim was to determine whether liver stiffness measurement (LSM) in hepatitis C virus (HCV)-infected patients is associated with a risk of LREs, particularly in cirrhotic patients. We carried out a retrospective study on 343 HCV-infected patients stratified according to cirrhosis (LSM<12.5 kPa vs. LSM≥12.5 kPa), and the cirrhotic patient group (LSM≥12.5 kPa) was divided according to risk of esophageal varices (LSM <25 kPa vs. LSM≥25 kPa). For all patients, each incremental unit in the natural logarithm (Ln) of LSM was associated with 14.76 times higher risk of developing LREs (p<0.001). Patients with cirrhosis (LSM≥12.5 kPa) had a higher risk of LREs than patients without cirrhosis (LSM<12.5 kPa) [adjusted hazard ratio (aHR) = 30.97; p<0.001]. When only cirrhotic patients were analyzed (n = 60), each incremental unit in the Ln of LSM was associated with 10.56 times higher risk of developing LREs (p = 0.010). Patients with LSM≥25 kPa had a greater risk for LRE development compared to those with LSM<25 kPa (aHR = 3.65; p = 0.045). The AUROC for predicting the onset of LREs was 0.876 in all patients and 0.729 in cirrhotic patients. In conclusion, LSM was associated with an increased risk of developing LREs in HCV-infected patients, even within the group of cirrhotic patients.es_ES
dc.description.sponsorshipThis work has been supported by grants given by Instituto de Salud Carlos III [grant numbers PI14CIII/00011 and CD13/00013].es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAdult es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHepatitis B, Chronic es_ES
dc.subject.meshHepatitis C, Chronic es_ES
dc.subject.meshHumans es_ES
dc.subject.meshKaplan-Meier Estimate es_ES
dc.subject.meshLiver es_ES
dc.subject.meshLiver Cirrhosis es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshProportional Hazards Models es_ES
dc.subject.meshROC Curve es_ES
dc.subject.meshRetrospective Studies es_ES
dc.titleLiver stiffness measurement predicts liver-related events in patients with chronic hepatitis C: A retrospective studyes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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Atribución 4.0 Internacional
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