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dc.contributor.authorGarcía-Arenzana, Nicolás
dc.contributor.authorNavarrete-Muñoz, Eva María
dc.contributor.authorLope, Virginia 
dc.contributor.authorMoreo, Pilar
dc.contributor.authorVidal, Carmen
dc.contributor.authorLaso-Pablos, Soledad
dc.contributor.authorAscunce, Nieves
dc.contributor.authorCasanova-Gómez, Francisco
dc.contributor.authorSánchez-Contador, Carmen
dc.contributor.authorSantamariña, Carmen
dc.contributor.authorAragones, Nuria 
dc.contributor.authorPerez-Gomez, Beatriz 
dc.contributor.authorVioque, Jesús
dc.contributor.authorPollan-Santamaria, Marina
dc.identifier.citationInt J Cancer. 2014; 134(8): 1916–1925.es_ES
dc.description.abstractHigh mammographic density (MD) is one of the main risk factors for development of breast cancer. To date, however, relatively few studies have evaluated the association between MD and diet. In this cross-sectional study, we assessed the association between MD (measured using Boyd's semiquantitative scale with five categories: <10%, 10-25%, 25-50%, 50-75% and >75%) and diet (measured using a food frequency questionnaire validated in a Spanish population) among 3,548 peri- and postmenopausal women drawn from seven breast cancer screening programs in Spain. Multivariate ordinal logistic regression models, adjusted for age, body mass index (BMI), energy intake and protein consumption as well as other confounders, showed an association between greater calorie intake and greater MD [odds ratio (OR) = 1.23; 95% confidence interval (CI) = 1.10-1.38, for every increase of 500 cal/day], yet high consumption of olive oil was nevertheless found to reduce the prevalence of high MD (OR = 0.86;95% CI = 0.76-0.96, for every increase of 22 g/day in olive oil consumption); and, while greater intake of whole milk was likewise associated with higher MD (OR = 1.10; 95%CI 1.00-1.20, for every increase of 200 g/day), higher consumption of protein (OR = 0.89; 95% CI 0.80-1.00, for every increase of 30 g/day) and white meat (p for trend 0.041) was found to be inversely associated with MD. Our study, the largest to date to assess the association between diet and MD, suggests that MD is associated with modifiable dietary factors, such as calorie intake and olive oil consumption. These foods could thus modulate the prevalence of high MD, and important risk marker for breast cancer.es_ES
dc.description.sponsorshipGrant sponsor: Spain’s Health Research Fund (Fondo de Investigación Sanitaria);Grant numbers:FIS PI060386 & FIS PIS09/01006; Collaboration Agreement between Astra-Zeneca and the Carlos III Institute of Health (Instituto de Salud Carlos III);Grant number: EPY 1306/06; Spanish Federation of Breast Cancer patients; Grant number: FECMA 485 EPY 1170-10es_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subjectBreast densityes_ES
dc.subjectCalorie intakees_ES
dc.subjectMammographic densityes_ES
dc.subjectOlive oiles_ES
dc.subject.meshAnimals es_ES
dc.subject.meshBiomarkers es_ES
dc.subject.meshBody Mass Index es_ES
dc.subject.meshBreast Density es_ES
dc.subject.meshBreast Neoplasms es_ES
dc.subject.meshCross-Sectional Studies es_ES
dc.subject.meshDiet es_ES
dc.subject.meshEnergy Intake es_ES
dc.subject.meshFeeding Behavior es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMammary Glands, Humanes_ES
dc.subject.meshMammography es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshOlive Oil es_ES
dc.subject.meshMilk es_ES
dc.subject.meshPlant Oils es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshSpain es_ES
dc.subject.meshSurveys and Questionnaires es_ES
dc.titleCalorie intake, olive oil consumption and mammographic density among Spanish womenes_ES
dc.rights.licenseAtribución-NoComercial-SinObraDerivada 4.0 Internacional*
dc.contributor.funderFondo de Investigación Sanitariaes_ES
dc.contributor.funderFederación Española de Cancer de Mamaes_ES
dc.identifier.journalInternational Journal of Canceres_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES

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Atribución-NoComercial-SinObraDerivada 4.0 Internacional
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