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dc.contributor.authorFernandez, Eva M 
dc.contributor.authorDíaz-Ceso, María D
dc.contributor.authorVilar, Marçal 
dc.date.accessioned2018-12-12T15:08:44Z
dc.date.available2018-12-12T15:08:44Z
dc.date.issued2015-01-22
dc.identifier.citationPLoS One. 2015 Jan 22;10(1):e0117206es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6829
dc.description.abstractIntrinsically disordered proteins (IDPs) are abundant in complex organisms. Due to their promiscuous nature and their ability to adopt several conformations IDPs constitute important points of network regulation. The family of Brain Expressed and X-linked (Bex) proteins consists of 5 members in humans (Bex1-5). Recent reports have implicated Bex proteins in transcriptional regulation and signaling pathways involved in neurodegeneration, cancer, cell cycle and tumor growth. However, structural and biophysical data for this protein family is almost non-existent. We used bioinformatics analyses to show that Bex proteins contain long regions of intrinsic disorder which are conserved across all members. Moreover, we confirmed the intrinsic disorder by circular dichroism spectroscopy of Bex1 after expression and purification in E. coli. These observations strongly suggest that Bex proteins constitute a new group of IDPs. Based on these findings, together with the demonstrated promiscuity of Bex proteins and their involvement in different signaling pathways, we propose that Bex family members play important roles in the formation of protein network hubs.es_ES
dc.description.sponsorshipMinistry of Economy and Competitiveness (MINECO) from the Government of Spain. Projects: BFU2010-15276 and BFU2013-42746-P to MV. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptes_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshCircular Dichroism es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMice es_ES
dc.subject.meshNerve Tissue Proteins es_ES
dc.subject.meshProtein Structure, Secondary es_ES
dc.subject.meshProtein Structure, Tertiary es_ES
dc.subject.meshRats es_ES
dc.subject.meshRecombinant Proteins es_ES
dc.subject.meshSignal Transduction es_ES
dc.titleBrain expressed and X-linked (Bex) proteins are intrinsically disordered proteins (IDPs) and form new signaling hubses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID25612294es_ES
dc.format.volume10es_ES
dc.format.number1es_ES
dc.format.pagee0117206es_ES
dc.identifier.doi10.1371/journal.pone.0117206es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1932-6203es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0117206es_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU-2010-15276es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BFU-2013-42746-Pes_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional