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dc.contributor.authorGherasim, Alin 
dc.contributor.authorMartínez-Baz, Iván
dc.contributor.authorCastilla, Jesús
dc.contributor.authorPozo Sánchez, Francisco 
dc.contributor.authorLarrauri, Amparo
dc.identifier.citationPLoS One. 2017 Jun 14;12(6):e0179160.es_ES
dc.description.abstractBACKGROUND: Recent studies suggest that the protective effect of the current influenza vaccine could be influenced by vaccination in previous seasons. We estimated the combined effect of the previous and current influenza vaccines from the 2010-2011 season to the 2015-2016 season in Spain. METHODS: We performed a test-negative case-control study in patients ≥9 years old. We estimated the influenza vaccine effectiveness (IVE) against influenza A(H1N1)pdm09, A(H3N2), and B virus. RESULTS: We included 1206 influenza A(H1N1)pdm09 cases, 1358 A(H3N2) cases and 1079 B cases. IVE against A(H1N1)pdm09 virus in the pooled-season analysis was 53% (95% Confidence Interval (CI): 21% to 72%) for those vaccinated only in the current season and 50% (95%CI: 23% to 68%) for those vaccinated in the both current and previous seasons. Against the influenza A(H3N2) virus, IVE was 17% (95%CI: -43% to 52%) for those vaccinated only in the current season and 3% (95%CI: -33% to 28%) for those vaccinated in both seasons. Regarding influenza B, we obtained similar IVEs for those vaccinated only in the current and those vaccinated in both seasons: 57% (95%CI: 12% to 79%) and 56% (95%CI: 36% to 70%), respectively. CONCLUSION: Our results suggested no interference between the previous and current influenza vaccines against A(H1N1)pdm09 and B viruses, but a possible negative interference against A(H3N2) virus.es_ES
dc.description.sponsorshipThis study was funded by the Horizon 2020 program of the European Commission (I-MOVE-plus, EU 634446) and by the European Centre for Disease Prevention and Control (I-MOVE, ECDC tender OJ/16/07/2014-Proc/2014/024).es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAdolescent es_ES
dc.subject.meshAdult es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshChild es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInfluenza A Virus, H1N1 Subtype es_ES
dc.subject.meshInfluenza A Virus, H3N2 Subtype es_ES
dc.subject.meshInfluenza B virus es_ES
dc.subject.meshInfluenza Vaccines es_ES
dc.subject.meshInfluenza, Humanes_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshSeasons es_ES
dc.subject.meshSentinel Surveillance es_ES
dc.subject.meshSpain es_ES
dc.subject.meshYoung Adult es_ES
dc.titleEffect of previous and current vaccination against influenza A(H1N1)pdm09, A(H3N2), and B during the post-pandemic period 2010-2016 in Spaines_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderEuropean Commission
dc.contributor.funderEuropean Centre for Disease Prevention and Control (ECDC)
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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