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dc.contributor.authorZhao, Di
dc.contributor.authorKim, Myung Hun
dc.contributor.authorPastor-Barriuso, Roberto 
dc.contributor.authorChang, Yoosoo
dc.contributor.authorRyu, Seungho
dc.contributor.authorZhang, Yiyi
dc.contributor.authorRampal, Sanjay
dc.contributor.authorShin, Hocheol
dc.contributor.authorKim, Joon Mo
dc.contributor.authorFriedman, David S
dc.contributor.authorGuallar, Eliseo 
dc.contributor.authorCho, Juhee
dc.identifier.citationPLoS One. 2016 Jan 5;11(1):e0146057es_ES
dc.description.abstractIMPORTANCE: Intraocular pressure (IOP) reduction or stabilization is the only proven method for glaucoma management. Identifying risk factors for IOP is crucial to understand the pathophysiology of glaucoma. OBJECTIVE: To examine the associations of change in body mass index (BMI), waist circumference, and percent fat mass with change in intraocular pressure (IOP) in a large sample of Korean adults. DESIGN, SETTING AND PARTICIPANTS: Cohort study of 274,064 young and middle age Korean adults with normal fundoscopic findings who attended annual or biennial health exams from January 1, 2002 to Feb 28, 2010 (577,981 screening visits). EXPOSURES: BMI, waist circumference, and percent fat mass. MAIN OUTCOME MEASURE(S): At each visit, IOP was measured in both eyes with automated noncontact tonometers. RESULTS: In multivariable-adjusted models, the average increase in IOP (95% confidence intervals) over time per interquartile increase in BMI (1.26 kg/m2), waist circumference (6.20 cm), and percent fat mass (3.40%) were 0.18 mmHg (0.17 to 0.19), 0.27 mmHg (0.26 to 0.29), and 0.10 mmHg (0.09 to 0.11), respectively (all P < 0.001). The association was stronger in men compared to women (P < 0.001) and it was only slightly attenuated after including diabetes and hypertension as potential mediators in the model. CONCLUSIONS AND RELEVANCE: Increases in adiposity were significantly associated with an increase in IOP in a large cohort of Korean adults attending health screening visits, an association that was stronger for central obesity. Further research is needed to understand better the underlying mechanisms of this association, and to establish the role of weight gain in increasing IOP and the risk of glaucoma and its complications.es_ES
dc.description.sponsorshipThe authors received no specific funding for this work.es_ES
dc.publisherPublic Library of Sciencees_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAdult es_ES
dc.subject.meshBody Mass Index es_ES
dc.subject.meshFemale es_ES
dc.subject.meshGlaucoma es_ES
dc.subject.meshHumans es_ES
dc.subject.meshLongitudinal Studies es_ES
dc.subject.meshMale es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshObesity es_ES
dc.subject.meshRepublic of Korea es_ES
dc.subject.meshRisk Factors es_ES
dc.subject.meshWaist Circumference es_ES
dc.subject.meshAdiposity es_ES
dc.subject.meshIntraocular Pressure es_ES
dc.titleA Longitudinal Study of Association between Adiposity Markers and Intraocular Pressure: The Kangbuk Samsung Health Studyes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemologíaes_ES

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Atribución 4.0 Internacional
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