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dc.contributor.author | Masiá, Mar | |
dc.contributor.author | Padilla, Sergio | |
dc.contributor.author | Fernández, Marta | |
dc.contributor.author | Moreno, Ana | |
dc.contributor.author | Oteo, Jose A | |
dc.contributor.author | Antela, Antonio | |
dc.contributor.author | Moreno, Santiago | |
dc.contributor.author | Amo, Julia del | |
dc.contributor.author | Gutiérrez, Félix | |
dc.contributor.author | Rodriguez-Blazquez, Carmen | |
dc.date.accessioned | 2018-12-10T09:55:45Z | |
dc.date.available | 2018-12-10T09:55:45Z | |
dc.date.issued | 2016-04-25 | |
dc.identifier.citation | PLoS One. 2016 Apr 25;11(4):e0153456 | es_ES |
dc.identifier.issn | 1932-6203 | es_ES |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6795 | |
dc.description.abstract | OBJECTIVE: We aimed to assess whether oxidative stress is a predictor of mortality in HIV-infected patients. METHODS: We conducted a nested case-control study in CoRIS, a contemporary, multicentre cohort of HIV-infected patients, antiretroviral-naïve at entry, launched in 2004. Cases were patients who died with available stored plasma samples collected. Two age and sex-matched controls for each case were selected. We measured F2-isoprostanes (F2-IsoPs) and malondialdehyde (MDA) plasma levels in the first blood sample obtained after cohort engagement. RESULTS: 54 cases and 93 controls were included. Median F2-IsoPs and MDA levels were significantly higher in cases than in controls. When adjustment was performed for age, HIV-transmission category, CD4 cell count and HIV viral load at cohort entry, and subclinical inflammation measured with highly-sensitive C-reactive protein (hsCRP), the association of F2-IsoPs with mortality remained significant (adjusted OR per 1 log10 increase, 2.34 [1.23-4.47], P = 0.009). The association of MDA with mortality was attenuated after adjustment: adjusted OR (95% CI) per 1 log10 increase, 2.05 [0.91-4.59], P = 0.080. Median hsCRP was also higher in cases, and it also proved to be an independent predictor of mortality in the adjusted analysis: OR (95% CI) per 1 log10 increase, 1.39 (1.01-1.91), P = 0.043; and OR (95% CI) per 1 log10 increase, 1.46 (1.07-1.99), P = 0.014, respectively, when adjustment included F2-IsoPs and MDA. CONCLUSION: Oxidative stress is a predictor of all-cause mortality in HIV-infected patients. For plasma F2-IsoPs, this association is independent of HIV-related factors and subclinical inflammation. | es_ES |
dc.description.sponsorship | This work has been (partially) funded by the RD12/0017/0023 project as part of the Plan Nacional R + D + I and cofinanced by ISCIII- Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER), FIS (PI08/893), FIS (PI13/02256), FISABIO UGP-14-197, and Contrato de Intensificación de la Actividad Investigadora INT 14/00207. The HIV Biobank, integrated in the RIS, is also supported by the ISCIII (RD06/0006/0035) and FIPSE. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science (PLOS) | es_ES |
dc.type.hasVersion | VoR | es_ES |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject.mesh | Adult | es_ES |
dc.subject.mesh | Case-Control Studies | es_ES |
dc.subject.mesh | F2-Isoprostanes | es_ES |
dc.subject.mesh | Female | es_ES |
dc.subject.mesh | HIV Infections | es_ES |
dc.subject.mesh | Humans | es_ES |
dc.subject.mesh | Male | es_ES |
dc.subject.mesh | Malondialdehyde | es_ES |
dc.subject.mesh | Middle Aged | es_ES |
dc.subject.mesh | Cause of Death | es_ES |
dc.subject.mesh | Oxidative Stress | es_ES |
dc.title | Oxidative Stress Predicts All-Cause Mortality in HIV-Infected Patients | es_ES |
dc.type | journal article | es_ES |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 27111769 | es_ES |
dc.format.volume | 11 | es_ES |
dc.format.number | 4 | es_ES |
dc.format.page | e0153456 | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0153456 | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | es_ES |
dc.identifier.e-issn | 1932-6203 | es_ES |
dc.relation.publisherversion | https://doi.org/10.1371/journal.pone.0153456 | es_ES |
dc.identifier.journal | PloS one | es_ES |
dc.repisalud.centro | ISCIII::Centro Nacional de Epidemiología | es_ES |
dc.repisalud.institucion | ISCIII | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI08/893 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI13/02256 | es_ES |
dc.rights.accessRights | open access | es_ES |