Mostrar el registro sencillo del ítem

dc.contributor.authorMasiá, Mar
dc.contributor.authorPadilla, Sergio
dc.contributor.authorFernández, Marta
dc.contributor.authorMoreno, Ana
dc.contributor.authorOteo, Jose A
dc.contributor.authorAntela, Antonio
dc.contributor.authorMoreno, Santiago
dc.contributor.authorAmo, Julia del 
dc.contributor.authorGutiérrez, Félix
dc.contributor.authorRodriguez-Blazquez, Carmen 
dc.date.accessioned2018-12-10T09:55:45Z
dc.date.available2018-12-10T09:55:45Z
dc.date.issued2016-04-25
dc.identifier.citationPLoS One. 2016 Apr 25;11(4):e0153456es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6795
dc.description.abstractOBJECTIVE: We aimed to assess whether oxidative stress is a predictor of mortality in HIV-infected patients. METHODS: We conducted a nested case-control study in CoRIS, a contemporary, multicentre cohort of HIV-infected patients, antiretroviral-naïve at entry, launched in 2004. Cases were patients who died with available stored plasma samples collected. Two age and sex-matched controls for each case were selected. We measured F2-isoprostanes (F2-IsoPs) and malondialdehyde (MDA) plasma levels in the first blood sample obtained after cohort engagement. RESULTS: 54 cases and 93 controls were included. Median F2-IsoPs and MDA levels were significantly higher in cases than in controls. When adjustment was performed for age, HIV-transmission category, CD4 cell count and HIV viral load at cohort entry, and subclinical inflammation measured with highly-sensitive C-reactive protein (hsCRP), the association of F2-IsoPs with mortality remained significant (adjusted OR per 1 log10 increase, 2.34 [1.23-4.47], P = 0.009). The association of MDA with mortality was attenuated after adjustment: adjusted OR (95% CI) per 1 log10 increase, 2.05 [0.91-4.59], P = 0.080. Median hsCRP was also higher in cases, and it also proved to be an independent predictor of mortality in the adjusted analysis: OR (95% CI) per 1 log10 increase, 1.39 (1.01-1.91), P = 0.043; and OR (95% CI) per 1 log10 increase, 1.46 (1.07-1.99), P = 0.014, respectively, when adjustment included F2-IsoPs and MDA. CONCLUSION: Oxidative stress is a predictor of all-cause mortality in HIV-infected patients. For plasma F2-IsoPs, this association is independent of HIV-related factors and subclinical inflammation.es_ES
dc.description.sponsorshipThis work has been (partially) funded by the RD12/0017/0023 project as part of the Plan Nacional R + D + I and cofinanced by ISCIII- Subdirección General de Evaluación y el Fondo Europeo de Desarrollo Regional (FEDER), FIS (PI08/893), FIS (PI13/02256), FISABIO UGP-14-197, and Contrato de Intensificación de la Actividad Investigadora INT 14/00207. The HIV Biobank, integrated in the RIS, is also supported by the ISCIII (RD06/0006/0035) and FIPSE. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAdult es_ES
dc.subject.meshCase-Control Studies es_ES
dc.subject.meshF2-Isoprostanes es_ES
dc.subject.meshFemale es_ES
dc.subject.meshHIV Infections es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshMalondialdehyde es_ES
dc.subject.meshMiddle Aged es_ES
dc.subject.meshCause of Death es_ES
dc.subject.meshOxidative Stress es_ES
dc.titleOxidative Stress Predicts All-Cause Mortality in HIV-Infected Patientses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27111769es_ES
dc.format.volume11es_ES
dc.format.number4es_ES
dc.format.pagee0153456es_ES
dc.identifier.doi10.1371/journal.pone.0153456es_ES
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1932-6203es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0153456es_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Epidemiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI08/893es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/02256es_ES
dc.rights.accessRightsopen accesses_ES


Ficheros en el ítem

Acceso Abierto
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional