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dc.contributor.authorFranco, Leticia 
dc.contributor.authorPalacios, Gustavo
dc.contributor.authorMartinez, José Antonio
dc.contributor.authorVazquez, Ana 
dc.contributor.authorSavji, Nazir
dc.contributor.authorDe Ory, Fernando de 
dc.contributor.authorSánchez-Seco, María Paz 
dc.contributor.authorMartín, Dolores
dc.contributor.authorLipkin, W Ian
dc.contributor.authorTenorio, Antonio
dc.identifier.citationPLoS Negl Trop Dis. 2011 Aug;5(8):e1251.es_ES
dc.description.abstractDengue virus (DENV) circulates in human and sylvatic cycles. Sylvatic strains are both ecologically and evolutionarily distinct from endemic viruses. Although sylvatic dengue cycles occur in West African countries and Malaysia, only a few cases of mild human disease caused by sylvatic strains and one single case of dengue hemorrhagic fever in Malaysia have been reported. Here we report a case of dengue hemorrhagic fever (DHF) with thrombocytopenia (13000/µl), a raised hematocrit (32% above baseline) and mucosal bleeding in a 27-year-old male returning to Spain in November 2009 after visiting his home country Guinea Bissau. Sylvatic DENV-2 West African lineage was isolated from blood and sera. This is the first case of DHF associated with sylvatic DENV-2 in Africa and the second case worldwide of DHF caused by a sylvatic strain.es_ES
dc.description.sponsorshipFinancial support was provided by the Fondo de Investigaciones Sanitarias (FIS) PI10/00069 and partially funded by FIS PI08/0834. LF is under contract by European Network of Imported Viral Disease-Collaborative Laboratory Response Network (ENIVD-CLRN) project funded by the European Centre for Disease Prevention and Control (ECDC) under the Framework Service Contract Ref. No. ECDC/2008/011. GP, NS and WIL were supported by, National Institutes of Health award AI57158 (Northeast Biodefense Center - Lipkin), and USAID Predict funding source code 07-301-7119-52258 (Center for Infection and Immunity) and the Department of Defense. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.subject.meshAdult es_ES
dc.subject.meshAntibodies, Viral es_ES
dc.subject.meshDengue Virus es_ES
dc.subject.meshEmigrants and Immigrants es_ES
dc.subject.meshEnvironment es_ES
dc.subject.meshEnzyme-Linked Immunosorbent Assay es_ES
dc.subject.meshGuinea-Bissau es_ES
dc.subject.meshHumans es_ES
dc.subject.meshMale es_ES
dc.subject.meshPhylogeny es_ES
dc.subject.meshPolymerase Chain Reaction es_ES
dc.subject.meshRNA, Viral es_ES
dc.subject.meshSevere Dengue es_ES
dc.subject.meshSpain es_ES
dc.subject.meshThrombocytopenia es_ES
dc.titleFirst report of sylvatic DENV-2-associated dengue hemorrhagic fever in West Africaes_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderInstituto de Salud Carlos III 
dc.identifier.journalPLoS neglected tropical diseaseses_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.rights.accessRightsopen accesses_ES

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