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dc.contributor.authorSalgueiro, Patrícia
dc.contributor.authorMoreno, Marta 
dc.contributor.authorSimard, Frédéric
dc.contributor.authorO'Brochta, David
dc.contributor.authorPinto, João
dc.identifier.citationPLoS One. 2013 Apr 26;8(4):e62964.es_ES
dc.description.abstractTransposable elements (TEs) are mobile portions of DNA that are able to replicate and spread in the genome of many organisms. TEs can be used as a means to insert transgenes in insects, being stably inherited throughout generations. Anopheles gambiae is the main vector of human malaria in Sub-Saharan Africa. Given the extraordinary burden this disease imposes, the mosquito became a choice target for genetic control approaches with the purpose of reducing malaria transmission. In this study, we investigated the abundance and distribution of Herves TE in An. gambiae s.s. from Cameroon and four islands in the Gulf of Guinea, in order to determine their genetic structure. We have detected a population subdivision between Equatorial Guinea islands and the islands of São Tomé, Príncipe and mainland. This partitioning associates more with political rather than geographic boundaries, possibly reflecting different mainland source populations colonizing the islands.es_ES
dc.description.sponsorshipThis work received financial support from the UNICEF/UNDP/World Bank/WHO Special Program for Research and Training in Tropical Diseases (TDR, A50239) and CMDT/IHMT Plurianual Program funds, as well as the US National Institutes of Health grant GM48102. PS was funded by a post-doc fellowship (SFRH/BPD/72532/2010) from Fundação para a Ciência e Tecnologia (FCT) through the European Program FEDER. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.subject.meshAnimals es_ES
dc.subject.meshAnopheles es_ES
dc.subject.meshDNA Transposable Elements es_ES
dc.subject.meshGenetic Variation es_ES
dc.subject.meshGenotype es_ES
dc.subject.meshGeography es_ES
dc.subject.meshGuinea es_ES
dc.subject.meshHumans es_ES
dc.subject.meshPopulation Dynamics es_ES
dc.subject.meshPrincipal Component Analysis es_ES
dc.subject.meshIslands es_ES
dc.titleNew insights into the population structure of Anopheles gambiae s.s. in the Gulf of Guinea Islands revealed by Herves transposable elementses_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.contributor.funderFundação para a Ciência e Tecnologia (Portugal) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderUnited Nations Development Programme 
dc.contributor.funderUNICEF - Fondo de las Naciones Unidas para la Infancia 
dc.contributor.funderWorld Health Organization (WHO/OMS) 
dc.contributor.funderWorld Bank Group 
dc.contributor.funderNational Institutes of Health (Estados Unidos) 
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Medicina Tropicales_ES
dc.rights.accessRightsopen accesses_ES

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Atribución 4.0 Internacional
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