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dc.contributor.authorSevá, Anaiá P
dc.contributor.authorOvallos, Fredy G
dc.contributor.authorAmaku, Marcus
dc.contributor.authorCarrillo, Eugenia 
dc.contributor.authorMoreno, Javier 
dc.contributor.authorGalati, Eunice A B
dc.contributor.authorLopes, Estela G
dc.contributor.authorSoares, Rodrigo M
dc.contributor.authorFerreira, Fernando
dc.date.accessioned2018-11-23T10:31:47Z
dc.date.available2018-11-23T10:31:47Z
dc.date.issued2016
dc.identifier.citationPLoS One. 2016 Jul 29;11(7):e0160058.es_ES
dc.identifier.issn1932-6203es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6707
dc.descriptionCorrection: Canine-Based Strategies for Prevention and Control of Visceral Leishmaniasis in Brazil. PLoS One. 2016 Sep 8;11(9):e0162854. doi: 10.1371/journal.pone.0162854. PMID: 27606898.
dc.description.abstractVisceral leishmaniasis (VL) is a zoonosis found worldwide. Its incidence has increased in Brazil in recent years, representing a serious public and animal health problem. The strategies applied in Brazil are questionable and are not sufficient to control the disease. Thus, we have compared the efficacy of some of the currently available strategies focused on dogs to prevent and control zoonotic VL in endemic areas by optimizing a mathematical model. The simulations showed that the elimination of seropositive dogs, the use of insecticide-impregnated dog collars, and the vaccination of dogs significantly contribute to reducing the prevalence of infection in both canines and humans. The use of insecticide-impregnated collars presented the highest level of efficacy mainly because it directly affected the force of infection and vector-dog contact. In addition, when used at a coverage rate of 90%, insecticide-impregnated collar was able to decrease the prevalence of seropositive dogs and humans to zero; moreover, because of the easy application and acceptance by the targeted population, these collars may be considered the most feasible for inclusion in public policies among the three simulated measures. Vaccination and euthanasia were efficacious, but the latter method is strongly criticized on ethical grounds, and both methods present difficulties for inclusion in public policies. When we compared the use of euthanasia and vaccination at coverages of 70 and 90%, respectively, the proportion of infected populations were similar. However, on evaluating the implications of both of these methods, particularly the negative aspects of culling dogs and the proportion of animals protected by vaccination, the latter measure appears to be the better option if the total cost is not significantly higher. The comparison of complications and advantages of different control strategies allows us to analyze the optimal measure and offer strategies to veterinary and public health authorities for making decisions to prevent and control zoonotic VL. Hence, improvements in both public and animal health can be achieved in regions with scenarios similar to that considered in the present study; such scenarios are characteristically found in some areas of Brazil and other countries.es_ES
dc.description.sponsorshipThis work was supported by the National Council for Scientific and Technological Development - Brazil (CNPq, 142612/2010-3), the Coordination for the Improvement of Higher Education Personnel - Brazil (CAPES, Fellowship BEX 9803/11-4), and the São Paulo Research Foundation -Brazil (FAPESP, 2012/01442-4). The funders had role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Science (PLOS) es_ES
dc.type.hasVersionVoRes_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subject.meshAnimals es_ES
dc.subject.meshBrazil es_ES
dc.subject.meshDog Diseases es_ES
dc.subject.meshDogs es_ES
dc.subject.meshHumans es_ES
dc.subject.meshInsecticides es_ES
dc.subject.meshLeishmaniasis, Visceral es_ES
dc.subject.meshVaccination es_ES
dc.titleCanine-Based Strategies for Prevention and Control of Visceral Leishmaniasis in Braziles_ES
dc.typejournal articlees_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID27471852es_ES
dc.format.volume11es_ES
dc.format.number7es_ES
dc.format.pagee0160058es_ES
dc.identifier.doi10.1371/journal.pone.0160058es_ES
dc.contributor.funderCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (Brasil) 
dc.contributor.funderNational Council for Scientific and Technological Development (Brasil) 
dc.contributor.funderSão Paulo Research Foundation 
dc.description.peerreviewedes_ES
dc.identifier.e-issn1932-6203es_ES
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0160058es_ES
dc.identifier.journalPloS onees_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES
dc.repisalud.institucionISCIIIes_ES
dc.rights.accessRightsopen accesses_ES


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