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dc.contributor.authorCasquero-Veiga, Marta
dc.contributor.authorGarcía-García, David
dc.contributor.authorDesco, Manuel 
dc.contributor.authorLuisa Soto-Montenegro, Maria
dc.date.accessioned2018-11-22T08:10:54Z
dc.date.available2018-11-22T08:10:54Z
dc.date.issued2018
dc.identifierISI:000448591200001
dc.identifier.citationBiomed Res Int. 2018; 2018:8560232
dc.identifier.issn2314-6133
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6696
dc.description.abstractDeep brain stimulation (DBS) is a neurosurgery technique widely used in movement disorders, although its mechanism of action remains unclear. In fact, apart from the stimulation itself, the mechanical insertion of the electrode may play a crucial role. Here we aimed to distinguish between the insertional and the DBS effects on brain glucose metabolism. To this end, electrodes were implanted targeting the medial prefrontal cortex in five adult male Wistar rats. Positron Emission Tomography (PET) studies were performed before surgery (D0) and seven (D7) and nine days (D9) after that. DBS was applied during the (18)FDG uptake of the D9 study. PET data were analysed with statistical parametric mapping. We found an electrode insertional effect in cortical areas, while DBS resulted in a more widespread metabolic pattern. The consequences of simultaneous electrode and DBS factors revealed a combination of both effects. Therefore, the insertion metabolic effects differed from the stimulation ones, which should be considered when assessing DBS protocols.
dc.description.sponsorshipThe authors thank Kenia Martinez for her help in performing the statistical analyses and the interpretation of the results; Alexandra de Francisco and Yolanda Sierra for their support in stereotaxic surgery, animal handling, and acquisition of imaging studies. This research was supported by Fundacion Mapfre, Alicia Koplowitz [FAK16/01], CIBER de Salud Mental (CIBERSAM), the Ministry of Economy and Competitiveness ISCIII-FIS Grants [PI14/00860, CPII14/00005, and PI17/01766], and Delegacion del Gobierno para el Plan Nacional sobre Drogas [PNSD 2017/085] and cofinanced by ERDF (FEDER) Funds from the European Commission, ``A way of Making Europe,´´ and Comunidad de Madrid [BRADE-CMS2013/ICE-2958].
dc.language.isoeng
dc.publisherHindawi 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleUnderstanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30417016
dc.identifier.doi10.1155/2018/8560232
dc.contributor.funderFundación Mapfre 
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderPlan Nacional de Drogas (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderFundación Alicia Koplowitz 
dc.contributor.funderInstituto de Salud Carlos III 
dc.description.peerreviewed
dc.identifier.e-issn2314-6141
dc.relation.publisherversionhttps://doi.org/10.1155/2018/8560232
dc.identifier.journalBIOMED RESEARCH INTERNATIONAL
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzada
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI14/00860es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CPII14/00005es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/01766es_ES
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional