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dc.contributor.author | Casquero-Veiga, Marta | |
dc.contributor.author | García-García, David | |
dc.contributor.author | Desco, Manuel | |
dc.contributor.author | Luisa Soto-Montenegro, Maria | |
dc.date.accessioned | 2018-11-22T08:10:54Z | |
dc.date.available | 2018-11-22T08:10:54Z | |
dc.date.issued | 2018 | |
dc.identifier | ISI:000448591200001 | |
dc.identifier.citation | Biomed Res Int. 2018; 2018:8560232 | |
dc.identifier.issn | 2314-6133 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6696 | |
dc.description.abstract | Deep brain stimulation (DBS) is a neurosurgery technique widely used in movement disorders, although its mechanism of action remains unclear. In fact, apart from the stimulation itself, the mechanical insertion of the electrode may play a crucial role. Here we aimed to distinguish between the insertional and the DBS effects on brain glucose metabolism. To this end, electrodes were implanted targeting the medial prefrontal cortex in five adult male Wistar rats. Positron Emission Tomography (PET) studies were performed before surgery (D0) and seven (D7) and nine days (D9) after that. DBS was applied during the (18)FDG uptake of the D9 study. PET data were analysed with statistical parametric mapping. We found an electrode insertional effect in cortical areas, while DBS resulted in a more widespread metabolic pattern. The consequences of simultaneous electrode and DBS factors revealed a combination of both effects. Therefore, the insertion metabolic effects differed from the stimulation ones, which should be considered when assessing DBS protocols. | |
dc.description.sponsorship | The authors thank Kenia Martinez for her help in performing the statistical analyses and the interpretation of the results; Alexandra de Francisco and Yolanda Sierra for their support in stereotaxic surgery, animal handling, and acquisition of imaging studies. This research was supported by Fundacion Mapfre, Alicia Koplowitz [FAK16/01], CIBER de Salud Mental (CIBERSAM), the Ministry of Economy and Competitiveness ISCIII-FIS Grants [PI14/00860, CPII14/00005, and PI17/01766], and Delegacion del Gobierno para el Plan Nacional sobre Drogas [PNSD 2017/085] and cofinanced by ERDF (FEDER) Funds from the European Commission, ``A way of Making Europe,´´ and Comunidad de Madrid [BRADE-CMS2013/ICE-2958]. | |
dc.language.iso | eng | |
dc.publisher | Hindawi | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.title | Understanding Deep Brain Stimulation: In Vivo Metabolic Consequences of the Electrode Insertional Effect | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30417016 | |
dc.identifier.doi | 10.1155/2018/8560232 | |
dc.contributor.funder | Fundación Mapfre | |
dc.contributor.funder | Centro de Investigación Biomedica en Red - CIBER | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Plan Nacional de Drogas (España) | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Fundación Alicia Koplowitz | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.description.peerreviewed | Sí | |
dc.identifier.e-issn | 2314-6141 | |
dc.relation.publisherversion | https://doi.org/10.1155/2018/8560232 | |
dc.identifier.journal | BIOMED RESEARCH INTERNATIONAL | |
dc.repisalud.orgCNIC | CNIC::Unidades técnicas::Imagen Avanzada | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI14/00860 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/CPII14/00005 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/PI17/01766 | es_ES |
dc.rights.accessRights | open access | es_ES |