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dc.contributor.authorMartinez-Mateu, Laura
dc.contributor.authorRomero, Lucia
dc.contributor.authorFerrer-Albero, Ana
dc.contributor.authorSebastian, Rafael
dc.contributor.authorRodriguez Matas, Jose F.
dc.contributor.authorJalife, Jose 
dc.contributor.authorBerenfeld, Omer
dc.contributor.authorSaiz, Javier
dc.date.accessioned2018-11-22T08:10:53Z
dc.date.available2018-11-22T08:10:53Z
dc.date.issued2018
dc.identifierISI:000428885200025
dc.identifier.citationPLoS Comput Biol. 2018; 14(3):e1006017
dc.identifier.issn1553-7358
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6685
dc.description.abstractAnatomically based procedures to ablate atrial fibrillation (AF) are often successful in terminating paroxysmal AF. However, the ability to terminate persistent AF remains disappointing. New mechanistic approaches use multiple-electrode basket catheter mapping to localize and target AF drivers in the form of rotors but significant concerns remain about their accuracy. We aimed to evaluate how electrode-endocardium distance, far-field sources and inter-electrode distance affect the accuracy of localizing rotors. Sustained rotor activation of the atria was simulated numerically and mapped using a virtual basket catheter with varying electrode densities placed at different positions within the atrial cavity. Unipolar electrograms were calculated on the entire endocardial surface and at each of the electrodes. Rotors were tracked on the interpolated basket phase maps and compared with the respective atrial voltage and endocardial phase maps, which served as references. Rotor detection by the basket maps varied between 35-94\% of the simulation time, depending on the basket's position and the electrode-to-endocardial wall distance. However, two different types of phantom rotors appeared also on the basket maps. The first type was due to the far-field sources and the second type was due to interpolation between the electrodes; increasing electrode density decreased the incidence of the second but not the first type of phantom rotors. In the simulations study, basket catheter-based phase mapping detected rotors even when the basket was not in full contact with the endocardial wall, but always generated a number of phantom rotors in the presence of only a single real rotor, which would be the desired ablation target. Phantom rotors may mislead and contribute to failure in AF ablation procedures.
dc.description.sponsorshipThis work was partially supported by: Programa Prometeu de la Conselleria d'Educacio Formacio I Ocupacio, Generalitat Valenciana (www.edu.gva.es/fio/index\_es.asp). Award Number: PROMETEU/2016/088 to JS;´´Plan Estatal de Investigacion Cientifica y Tecnica y de Innovacion 2013-2016´´ from the Ministerio de Economia, Industria y Competitividad of Spain, Agencia Estatal de Investigacion (www.mineco.gob.es) and the European Commission (European Regional Development Funds - ERDF -FEDER) (ec.europa.eu/regional\_policy/es/funding/erdf/) Award Number: DPI2016-75799-R to JS; ``Programa Estatal de Investigacion, Desarrollo e Innovacion Orientado a los Retos de la Sociedad´´ from the Ministerio de Economia y Competitividad of Spain, Agencia Estatal de Investigacion (www.mineco.gob.es) and the European Commission (European Regional Development Funds - ERDF -FEDER) (ec.europa.eu/regional\_policy/es/funding/erdf/) Award Number: TIN2014-59932-JIN to RS; National Institutes of Health (https://www.nih.gov/grants-funding). Award Numbers: R01-HL122352, P01-HL039707, P01-HL087236 and R01-HL118304 to OB; and research grant from Medtronic, Inc. (http://www.medtronic.com/us-en/about/foundation.html) to OB and JJ. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.titleFactors affecting basket catheter detection of real and phantom rotors in the atria: A computational study
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29505583
dc.format.volume14
dc.identifier.doi10.1371/journal.pcbi.1006017
dc.contributor.funderGeneralitat Valenciana
dc.contributor.funderMinisterio de Economia, Industria y Competitividad (España)
dc.contributor.funderEuropean Commission
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderAgencia Estatal de Investigacion
dc.contributor.funderNational Institutes of Health (United States)
dc.contributor.funderMedtronic, Inc.
dc.contributor.funderEuropean Regional Development Funds (ERDF/FEDER)
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pcbi.1006017
dc.identifier.journalPLoS Computational Biology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Arritmias Cardíacas
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/DPI2016-75799-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/TIN2014-59932-JINes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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