Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/6674
Title
Flexible Signaling of Myeloid C-Type Lectin Receptors in Immunity and Inflammation
Author(s)
del Fresno, Carlos CNIC | Iborra, Salvador CNIC | Saz-Leal, Paula CNIC | Martinez-Lopez, Maria CNIC | Sancho, David CNIC
Date issued
2018
Citation
Front Immunol. 2018; 9:804
Language
Inglés
Document type
journal article
Abstract
Myeloid C-type lectin receptors (CLRs) are important sensors of self and non-self that work in concert with other pattern recognition receptors (PRRs). CLRs have been previously classified based on their signaling motifs as activating or inhibitory receptors. However, specific features of the ligand binding process may result in distinct signaling through a single motif, resulting in the triggering of non-canonical pathways. In addition, CLR ligands are frequently exposed in complex structures that simultaneously bind different CLRs and other PRRs, which lead to integration of heterologous signaling among diverse receptors. Herein, we will review how sensing by myeloid CLRs and crosstalk with heterologous receptors is modulated by many factors affecting their signaling and resulting in differential outcomes for immunity and inflammation. Finding common features among those flexible responses initiated by diverse CLR-ligand partners will help to harness CLR function in immunity and inflammation.
Subject
Lectin receptors | Signaling | Monocytes | Macrophages | Dendritic cells | Innate immunity | Inflammation | PATTERN-RECOGNITION RECEPTOR | MYCOBACTERIAL CORD FACTOR | DENDRITIC CELL IMMUNORECEPTOR | INNATE ANTIFUNGAL IMMUNITY | BETA-GLUCAN RECEPTOR | TOLL-LIKE RECEPTOR-2 | SYK TYROSINE KINASE | CANDIDA-ALBICANS | DC-SIGN | HOST-DEFENSE
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