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dc.contributor.authorSalinas-Munoz, Laura
dc.contributor.authorCampos-Fernandez, Raul
dc.contributor.authorMercader, Enrique
dc.contributor.authorOlivera-Valle, Irene
dc.contributor.authorFernandez-Pacheco, Carlota
dc.contributor.authorMatilla, Lara
dc.contributor.authorGarcia-Bordas, Julio
dc.contributor.authorBrazil, Jennifer C.
dc.contributor.authorParkos, Charles A.
dc.contributor.authorAsensio, Fernando
dc.contributor.authorMunoz-Fernandez, Maria A.
dc.contributor.authorHidalgo, Andres 
dc.contributor.authorSanchez-Mateos, Paloma
dc.contributor.authorSamaniego, Rafael
dc.contributor.authorRelloso, Miguel
dc.date.accessioned2018-11-22T08:10:50Z
dc.date.available2018-11-22T08:10:50Z
dc.date.issued2018
dc.identifierISI:000432943700001
dc.identifier.citationFront Immunol. 2018; 9:1033
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6666
dc.description.abstractEstradiol-based therapies predispose women to vaginal infections. Moreover, it has long been known that neutrophils are absent from the vaginal lumen during the ovulatory phase (high estradiol). However, the mechanisms that regulate neutrophil influx to the vagina remain unknown. We investigated the neutrophil transepithelial migration (TEM) into the vaginal lumen. We revealed that estradiol reduces the CD44 and CD47 epithelial expression in the vaginal ectocervix and fornix, which retain neutrophils at the apical epithelium through the estradiol receptor-alpha. In contrast, luteal progesterone increases epithelial expression of CD44 and CD47 to promote neutrophil migration into the vaginal lumen and Candida albicans destruction. Distinctive to vaginal mucosa, neutrophil infiltration is contingent to sex hormones to prevent sperm from neutrophil attack; although it may compromise immunity during ovulation. Thus, sex hormones orchestrate tolerance and immunity in the vaginal lumen by regulating neutrophil TEM.
dc.description.sponsorshipThe authors thank the units of flow cytometry, cell culture and statistical analysis. We are grateful to J. Villarejo, M. Fernandez-Garcia, and F. Sanchez-Cobos, for expert help and support. This work was partially supported by Fundacion Mutua Madrilena and the Ministry of Economy and Competitiveness ISCIII-FIS grants PI13/00269, PI16/00050, and PI17/01324, co-financed by ERDF (FEDER) Funds from the European Commission, ``A way of making Europe.´´ MR holds a Miguel Servet II contract (CPII14/00009). LS-M holds a IiSGM intramural contract.
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectestradiol
dc.subjectESR1
dc.subjectprogesterone
dc.subjectneutrophils
dc.subjecttransepithelial migration
dc.subjectcervix
dc.subjectNEUTROPHIL-EPITHELIAL INTERACTIONS
dc.subjectTRANSEPITHELIAL MIGRATION
dc.subjectSEX-HORMONES
dc.subjectINTESTINAL EPITHELIUM
dc.subjectCHEMOKINE GRADIENTS
dc.subjectVAGINA
dc.subjectTRANSMIGRATION
dc.subjectIMMUNITY
dc.subjectCELLS
dc.subjectINFILTRATION
dc.titleEstrogen Receptor-Alpha (ESR1) Governs the Lower Female Reproductive Tract Vulnerability to Candida albicans
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29881378
dc.format.volume9
dc.identifier.doi10.3389/fimmu.2018.01033
dc.contributor.funderFundación Mutua Madrileña Automovilista
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2018.01033
dc.identifier.journalFrontiers in Immunology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Imagen de la Inflamación Cardiovascular y la Respuesta Inmune
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI13/00269es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI16/00050es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/PI17/01324es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/CPII14/00009es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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