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dc.contributor.authorTravés, Paqui G
dc.contributor.authorLuque, Alfonso 
dc.contributor.authorHortelano, Sonsoles
dc.identifier.citationMediators Inflamm. 2012; Article ID:568783.es_ES
dc.description.abstractThe interaction between tumor progression and innate immune system has been well established in the last years. Indeed, several lines of clinical evidence indicate that immune cells such as tumor-associated macrophages (TAMs) interact with tumor cells, favoring growth, angiogenesis, and metastasis of a variety of cancers. In most tumors, TAMs show properties of an alternative polarization phenotype (M2) characterized by the expression of a series of chemokines, cytokines, and proteases that promote immunosuppression, tumor proliferation, and spreading of the cancer cells. Tumor suppressor genes have been traditionally linked to the regulation of cancer progression; however, a growing body of evidence indicates that these genes also play essential roles in the regulation of innate immunity pathways through molecular mechanisms that are still poorly understood. In this paper, we provide an overview of the immunobiology of TAMs as well as what is known about tumor suppressors in the context of immune responses. Recent advances regarding the role of the tumor suppressor ARF as a regulator of inflammation and macrophage polarization are also reviewed.es_ES
dc.description.sponsorshipThis study was supported by Grants PI11.0036 from the FIS and MPY 1410/09 from ISCIII to S. Hortelano.es_ES
dc.publisherHindawi Publishing Corporationes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.subject.meshAnimals es_ES
dc.subject.meshCyclin-Dependent Kinase Inhibitor p16 es_ES
dc.subject.meshHumans es_ES
dc.subject.meshImmune Tolerance es_ES
dc.subject.meshInflammation Mediators es_ES
dc.subject.meshMacrophages es_ES
dc.subject.meshNeoplasms es_ES
dc.subject.meshNeovascularization, Pathologic es_ES
dc.subject.meshTumor Microenvironment es_ES
dc.subject.meshTumor Suppressor Protein p14ARF es_ES
dc.subject.meshTumor Suppressor Proteins es_ES
dc.titleMacrophages, inflammation, and tumor suppressors: ARF, a new player in the gamees_ES
dc.rights.licenseAtribución-3.0 Internacional*
dc.contributor.funderFondo de Investigaciones Sanitarias
dc.identifier.journalMediators of inflammationes_ES
dc.repisalud.centroISCIII::Centro Nacional de Microbiologíaes_ES

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Atribución-3.0 Internacional
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