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dc.contributor.authorTorralba, Daniel 
dc.contributor.authorBaixauli, Francesc 
dc.contributor.authorVillarroya-Beltri, Carolina 
dc.contributor.authorFernandez-Delgado, Irene 
dc.contributor.authorLatorre-Pellicer, Ana 
dc.contributor.authorAcin-Perez, Rebeca 
dc.contributor.authorMartin-Cofreces, Noa B. 
dc.contributor.authorJaso-Tamame, Angel Luis
dc.contributor.authorIborra, Salvador 
dc.contributor.authorJorge, Inmaculada 
dc.contributor.authorGonzalez-Aseguinolaza, Gloria
dc.contributor.authorGaraude, Johan 
dc.contributor.authorVicente-Manzanares, Miguel
dc.contributor.authorEnriquez, Jose Antonio 
dc.contributor.authorMittelbrunn, Maria
dc.contributor.authorSanchez-Madrid, Francisco 
dc.date.accessioned2018-11-05T11:58:20Z
dc.date.available2018-11-05T11:58:20Z
dc.date.issued2018
dc.identifierISI:000437834400005
dc.identifier.citationNat Commun. 2018; 9(1):2658
dc.identifier.issn2041-1723
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6572
dc.description.abstractInteraction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.
dc.description.sponsorshipWe thank Dr. S. Bartlett for assistance with English editing and Dr A. Garcia-Sastre for providing reagents. This study was supported by grants SAF2017/82886-R from the Spanish Ministry of Economy and Competitiveness, CAM S2017/BMD-3671 from the Comunidad de Madrid, CIBER Cardiovascular (Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional FEDER), ERC-2011-AdG 294340-GENTRIS and COST-Action BM1202 to F.S.-M.; grant SAF2015-65633-R from the Spanish Ministry of Economy and Competitiveness to J.A.E. M.M. is supported by MS14/00219 from Instituto de Salud Carlos III. Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505).
dc.language.isoeng
dc.publisherNature Publishing Group 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMITOCHONDRIAL-DNA
dc.subjectIMMUNOLOGICAL SYNAPSE
dc.subjectIMMUNE-RESPONSES
dc.subjectCANCER-CELLS
dc.subjectIN-VIVO
dc.subjectKAPPA-B
dc.subjectEXOSOMES
dc.subjectRELEASE
dc.subjectINNATE
dc.subjectIDENTIFICATION
dc.titlePriming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29985392
dc.format.volume9
dc.identifier.doi10.1038/s41467-018-05077-9
dc.contributor.funderMinisterio de Economía y Competitividad (España) 
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderUnión Europea. Comisión Europea 
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderFundación ProCNIC 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1038/s41467-018-05077-9
dc.identifier.journalNature Communications
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovascular
dc.repisalud.orgCNICCNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativa
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/294340/EUes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/[SAF2017/82886-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SAF2015-65633-Res_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/MS14/00219es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/SEV-2015-0505es_ES
dc.rights.accessRightsopen accesses_ES


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