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dc.contributor.author | Torralba, Daniel | |
dc.contributor.author | Baixauli, Francesc | |
dc.contributor.author | Villarroya-Beltri, Carolina | |
dc.contributor.author | Fernandez-Delgado, Irene | |
dc.contributor.author | Latorre-Pellicer, Ana | |
dc.contributor.author | Acin-Perez, Rebeca | |
dc.contributor.author | Martin-Cofreces, Noa B. | |
dc.contributor.author | Jaso-Tamame, Angel Luis | |
dc.contributor.author | Iborra, Salvador | |
dc.contributor.author | Jorge, Inmaculada | |
dc.contributor.author | Gonzalez-Aseguinolaza, Gloria | |
dc.contributor.author | Garaude, Johan | |
dc.contributor.author | Vicente-Manzanares, Miguel | |
dc.contributor.author | Enriquez, Jose Antonio | |
dc.contributor.author | Mittelbrunn, Maria | |
dc.contributor.author | Sanchez-Madrid, Francisco | |
dc.date.accessioned | 2018-11-05T11:58:20Z | |
dc.date.available | 2018-11-05T11:58:20Z | |
dc.date.issued | 2018 | |
dc.identifier | ISI:000437834400005 | |
dc.identifier.citation | Nat Commun. 2018; 9(1):2658 | |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6572 | |
dc.description.abstract | Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats. | |
dc.description.sponsorship | We thank Dr. S. Bartlett for assistance with English editing and Dr A. Garcia-Sastre for providing reagents. This study was supported by grants SAF2017/82886-R from the Spanish Ministry of Economy and Competitiveness, CAM S2017/BMD-3671 from the Comunidad de Madrid, CIBER Cardiovascular (Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III and co-funding by Fondo Europeo de Desarrollo Regional FEDER), ERC-2011-AdG 294340-GENTRIS and COST-Action BM1202 to F.S.-M.; grant SAF2015-65633-R from the Spanish Ministry of Economy and Competitiveness to J.A.E. M.M. is supported by MS14/00219 from Instituto de Salud Carlos III. Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). | |
dc.language.iso | eng | |
dc.publisher | Nature Publishing Group | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | MITOCHONDRIAL-DNA | |
dc.subject | IMMUNOLOGICAL SYNAPSE | |
dc.subject | IMMUNE-RESPONSES | |
dc.subject | CANCER-CELLS | |
dc.subject | IN-VIVO | |
dc.subject | KAPPA-B | |
dc.subject | EXOSOMES | |
dc.subject | RELEASE | |
dc.subject | INNATE | |
dc.subject | IDENTIFICATION | |
dc.title | Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 29985392 | |
dc.format.volume | 9 | |
dc.identifier.doi | 10.1038/s41467-018-05077-9 | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Centro de Investigación Biomedica en Red - CIBER | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.1038/s41467-018-05077-9 | |
dc.identifier.journal | Nature Communications | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Proteómica cardiovascular | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Genética Funcional del Sistema de Fosforilación Oxidativa | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/294340/EU | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/[SAF2017/82886-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SAF2015-65633-R | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/MS14/00219 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/ES/SEV-2015-0505 | es_ES |
dc.rights.accessRights | open access | es_ES |