Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/6572
Title
Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts
Author(s)
Torralba, Daniel CNIC | Baixauli, Francesc CNIC | Villarroya-Beltri, Carolina CNIC | Fernandez-Delgado, Irene CNIC | Latorre-Pellicer, Ana CNIC | Acin-Perez, Rebeca CNIC | Martin-Cofreces, Noa B. CNIC | Jaso-Tamame, Angel Luis | Iborra, Salvador CNIC | Jorge, Inmaculada CNIC | Gonzalez-Aseguinolaza, Gloria | Garaude, Johan CNIC | Vicente-Manzanares, Miguel | Enriquez, Jose Antonio CNIC | Mittelbrunn, Maria | Sanchez-Madrid, Francisco CNIC
Date issued
2018
Citation
Nat Commun. 2018; 9(1):2658
Language
Inglés
Document type
journal article
Abstract
Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but whether this interaction has physiological consequences on DC function is largely unexplored. Here we show that when antigen-bearing DCs contact T cells, DCs initiate antipathogenic programs. Signals of this interaction are transmitted from the T cell to the DC, through extracellular vesicles (EV) that contain genomic and mitochondrial DNA, to induce antiviral responses via the cGAS/STING cytosolic DNA-sensing pathway and expression of IRF3-dependent interferon regulated genes. Moreover, EV-treated DCs are more resistant to subsequent viral infections. In summary, our results show that T cells prime DCs through the transfer of exosomal DNA, supporting a specific role for antigen-dependent contacts in conferring protection to DCs against pathogen infection. The reciprocal communication between innate and adaptive immune cells thus allow efficacious responses to unknown threats.
Subject
MITOCHONDRIAL-DNA | IMMUNOLOGICAL SYNAPSE | IMMUNE-RESPONSES | CANCER-CELLS | IN-VIVO | KAPPA-B | EXOSOMES | RELEASE | INNATE | IDENTIFICATION
Online version
DOI
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