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dc.contributor.authorRodriguez, Jose Manuel 
dc.contributor.authorRodriguez Rivas, Juan 
dc.contributor.authorDi Domenico, Tomás
dc.contributor.authorVazquez, Jesús 
dc.contributor.authorValencia, Alfonso 
dc.contributor.authorTress ML, Michael L 
dc.date.accessioned2018-10-30T10:32:28Z
dc.date.available2018-10-30T10:32:28Z
dc.date.issued2018-01-04
dc.identifier.citationNucleic Acids Res. 2018; 46 (D1): D213 - D217.es_ES
dc.identifier.issn0305-1048es_ES
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6551
dc.descriptionFUNDING National Institutes of Health [U41 HG007234, 2U41 HG007234]; Spanish Ministry of Economics and Com- petitiveness [BIO2015-67580-P]; Spanish National Institute of Bioinformatics (www.inab.org) [INB-ISCIII, PRB2 toJ.M.R.]; ProteoRed [IPT13/0001-ISCIII-SGEFI/FEDERto J.V.]; Joint BSC-IRB-CRG Program in Computational Downloaded from https://academic.oup.com/nar/article-abstract/46/D1/D213/4561658 by Spanish National Cancer Research Center user on 30 October 2018 Nucleic Acids Research, 2018, Vol. 46, Database issue D217 Biology and Award Severo Ochoa [SEV 2015-0493 to A.V.]. Funding for open access charge: U.S. Depart- ment of Health and Human Services; National Institutes of Health; National Human Genome Research Institute [2U41 HG007234]. Conflict of interest statement.None declared.es_ES
dc.description.abstractThe APPRIS database (http://appris-tools.org) uses protein structural and functional features and information from cross-species conservation to annotate splice isoforms in protein-coding genes. APPRIS selects a single protein isoform, the 'principal' isoform, as the reference for each gene based on these annotations. A single main splice isoform reflects the biological reality for most protein coding genes and APPRIS principal isoforms are the best predictors of these main proteins isoforms. Here, we present the updates to the database, new developments that include the addition of three new species (chimpanzee, Drosophila melangaster and Caenorhabditis elegans), the expansion of APPRIS to cover the RefSeq gene set and the UniProtKB proteome for six species and refinements in the core methods that make up the annotation pipeline. In addition APPRIS now provides a measure of reliability for individual principal isoforms and updates with each release of the GENCODE/Ensembl and RefSeq reference sets. The individual GENCODE/Ensembl, RefSeq and UniProtKB reference gene sets for six organisms have been merged to produce common sets of splice variants.es_ES
dc.language.isoenges_ES
dc.publisherOxford University Presses_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectPROTEIN-CODING GENESes_ES
dc.subjectEVOLUTIONARY INFORMATIONes_ES
dc.subjectFUNCTIONALLY IMPORTANTes_ES
dc.subjectSPLICE ISOFORMSes_ES
dc.subjectHUMAN GENOMEes_ES
dc.subjectDATABASEes_ES
dc.subjectCOMPLEXITYes_ES
dc.subjectPREDICTIONes_ES
dc.subjectTOPOLOGYes_ES
dc.subjectPROJECTes_ES
dc.titleAPPRIS 2017: principal isoforms for multiple gene setses_ES
dc.typeArtículoes_ES
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID29069475es_ES
dc.format.volume46es_ES
dc.format.numberD1es_ES
dc.format.pageD213-D217es_ES
dc.identifier.doi10.1093/nar/gkx997es_ES
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderInstituto Nacional de Bioinformática (España)es_ES
dc.contributor.funderInstituto de Salud Carlos III - ISCIIIes_ES
dc.contributor.funderNational Institutes of Health (United States)
dc.description.peerreviewed
dc.identifier.e-issn1362-4962es_ES
dc.relation.publisherversionhttps://doi.org/10.1093/nar/gkx997es_ES
dc.identifier.journalNucleic acids researches_ES
dc.repisalud.orgCNICCNIC::Grupos de investigación::Proteómica cardiovascular
dc.repisalud.institucionCNIOes_ES
dc.repisalud.institucionCNIC
dc.repisalud.orgCNIOCNIO::Grupos de investigaciónes_ES
dc.repisalud.orgCNIOCNIO::Grupos de investigación::Grupo de Biología Computacional Estructurales_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ES/BIO2015-67580-Pes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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