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dc.contributor.authorBello-Arroyo, Elisabet 
dc.contributor.authorRoque, Helio 
dc.contributor.authorMarcos, Alberto
dc.contributor.authorOrihuel, Javier
dc.contributor.authorHiguera-Matas, Alejandro
dc.contributor.authorDesco, Manuel 
dc.contributor.authorCaiolfa, Valeria R 
dc.contributor.authorAmbrosio, Emilio
dc.contributor.authorLara-Pezzi, Enrique 
dc.contributor.authorGomez-Gaviro, Maria Victoria
dc.date.accessioned2018-10-26T07:59:25Z
dc.date.available2018-10-26T07:59:25Z
dc.date.issued2018
dc.identifierISI:000444046500001
dc.identifier.citationFront Behav Neurosci. 2018; 12:201
dc.identifier.issn1662-5153
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6534
dc.description.abstractAnimal behavioral tests are essential to understand the bases of neurologic and psychological disorders, which can be evaluated by different methodological and experimental models. However, the quantification of behavioral tests results is limited by the considerable amount of time needed for manual evaluation and the high costs of automated analysis software. To overcome these limitations, we describe here a new, open source toolbox for ImageJ, called Mouse Behavioral Analysis Toolbox (MouBeAT), designed to analyze different behavioral tests in rodents semi-automatically. These tests include Open Field (OF), Elevated Plus Maze (EPM), Y-maze (YM) test and Morris Water Maze (MWM). MouBeAT showed a high correlation with manual evaluation in all the parameters analyzed for all the behavioral tests, reinforcing its value as an accurate analysis tool. This new tool is freely available online.
dc.description.sponsorshipThis study was funded by a grant from the Spanish Ministerio de Ciencia, Innovacion y Universidades to EL-P (SAF2015-65722-R), and grants from the Instituto de Salud Carlos III (RIC, RD12/0042/0057) and the Autonomous Region of Madrid (BRADE S2013/ICE-2958) to MD, as well as by Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM). This work was also supported by the Plan Estatal de I+D+I 2013-2016-European Regional Development Fund (FEDER) ``A way of making Europe,'' Spain. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministerio de Ciencia, Innovacion y Universidades and by the Pro-CNIC Foundation and is a Severo Ochoa Centre of Excellence (MINECO award SEV-2015-0505).
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectbehavioral tests
dc.subjectrodents
dc.subjectopen source
dc.subjectImageJ
dc.subjectsemi-automated analysis
dc.subjectOPEN-FIELD TEST
dc.subjectALZHEIMERS-DISEASE
dc.subjectRODENTS
dc.subjectMAZE
dc.subjectANIMALS
dc.subjectMODELS
dc.subjectSYSTEM
dc.subjectFEAR
dc.titleMouBeAT: A New and Open Toolbox for Guided Analysis of Behavioral Tests in Mice
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30245618
dc.format.volume12
dc.identifier.doi10.3389/fnbeh.2018.00201
dc.contributor.funderMinisterio de Ciencia, Innovación y Universidades (España)
dc.contributor.funderInstituto de Salud Carlos III - ISCIII
dc.contributor.funderComunidad de Madrid
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderEuropean Regional Development Fund (ERDF/FEDER)
dc.contributor.funderFundación ProCNIC
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.3389/fnbeh.2018.00201
dc.identifier.journalFrontiers in Behavioral Neuroscience
dc.repisalud.orgCNICCNIC::Grupos de investigación::Regulación Molecular de la Insuficiencia Cardiaca
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzada
dc.repisalud.orgCNICCNIC::Unidades técnicas::Microscopía
dc.repisalud.institucionCNIC
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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