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dc.contributor.author | Rodriguez-Galan, Ana | |
dc.contributor.author | Fernandez-Messina, Lola | |
dc.contributor.author | Sanchez-Madrid, Francisco | |
dc.date.accessioned | 2018-10-26T07:59:25Z | |
dc.date.available | 2018-10-26T07:59:25Z | |
dc.date.issued | 2018 | |
dc.identifier | ISI:000445610900001 | |
dc.identifier.citation | Front Immunol. 2018; 9:2148 | |
dc.identifier.issn | 1664-3224 | |
dc.identifier.uri | http://hdl.handle.net/20.500.12105/6532 | |
dc.description.abstract | MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules. | |
dc.description.sponsorship | We thank Dr M. Vicente-Manzanares for critical reading of the manuscript and for assistance with English editing. This study was supported by the following grants from the Spanish Ministry of Economy and Competitiveness, (grant SAF2017-82886-R to FSM), CIBER CARDIOVASCULAR and PIE 13.0004-BIOIMID from the Instituto de Salud Carlos III (Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III with co-funding from the Fondo Europeo de Desarrollo Regional; FEDER), Programa de Actividades en Biomedicina de la Comunidad de Madrid-B2017/BMD-3671-INFLAMUNE to FS-M, and ERC-2011-AdG294340-GENTRIS to FS-M. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECOaward SEV-2015-0505). AR-G is supported by the FPU program (Spanish Ministry of Education). LF-M is funded by the CIBER CARDIOVASCULAR. | |
dc.language.iso | eng | |
dc.publisher | Frontiers Media | |
dc.type.hasVersion | VoR | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | * |
dc.subject | T cell activation | |
dc.subject | MicroRNAs (miRNAs) | |
dc.subject | Immunoregulatory molecules | |
dc.subject | miRNA signature | |
dc.subject | CD4 | |
dc.subject | CD8 | |
dc.subject | T lymphocyte | |
dc.subject | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | |
dc.subject | SYSTEMIC-LUPUS-ERYTHEMATOSUS | |
dc.subject | MICRORNA-MEDIATED REGULATION | |
dc.subject | IMMUNE-RESPONSE | |
dc.subject | TGF-BETA | |
dc.subject | MULTIPLE-SCLEROSIS | |
dc.subject | RNA-INTERFERENCE | |
dc.subject | GENE-EXPRESSION | |
dc.subject | DOWN-REGULATION | |
dc.subject | CYTOKINE PRODUCTION | |
dc.title | Control of Immunoregulatory Molecules by miRNAs in T Cell Activation | |
dc.type | journal article | |
dc.rights.license | Atribución 4.0 Internacional | * |
dc.identifier.pubmedID | 30319616 | |
dc.format.volume | 9 | |
dc.identifier.doi | 10.3389/fimmu.2018.02148 | |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | |
dc.contributor.funder | Centro de Investigación Biomedica en Red - CIBER | |
dc.contributor.funder | Instituto de Salud Carlos III | |
dc.contributor.funder | Comunidad de Madrid (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea. European Research Council (ERC) | |
dc.contributor.funder | Fundación ProCNIC | |
dc.contributor.funder | Ministerio de Educación (España) | |
dc.contributor.funder | Unión Europea. Comisión Europea | |
dc.description.peerreviewed | Sí | |
dc.relation.publisherversion | https://doi.org/10.3389/fimmu.2018.02148 | |
dc.identifier.journal | Frontiers in Immunology | |
dc.repisalud.orgCNIC | CNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria | |
dc.repisalud.institucion | CNIC | |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/294340/EU | es_ES |
dc.rights.accessRights | open access | es_ES |