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dc.contributor.authorRodriguez-Galan, Ana 
dc.contributor.authorFernandez-Messina, Lola 
dc.contributor.authorSanchez-Madrid, Francisco 
dc.date.accessioned2018-10-26T07:59:25Z
dc.date.available2018-10-26T07:59:25Z
dc.date.issued2018
dc.identifierISI:000445610900001
dc.identifier.citationFront Immunol. 2018; 9:2148
dc.identifier.issn1664-3224
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6532
dc.description.abstractMiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.
dc.description.sponsorshipWe thank Dr M. Vicente-Manzanares for critical reading of the manuscript and for assistance with English editing. This study was supported by the following grants from the Spanish Ministry of Economy and Competitiveness, (grant SAF2017-82886-R to FSM), CIBER CARDIOVASCULAR and PIE 13.0004-BIOIMID from the Instituto de Salud Carlos III (Fondo de Investigacion Sanitaria del Instituto de Salud Carlos III with co-funding from the Fondo Europeo de Desarrollo Regional; FEDER), Programa de Actividades en Biomedicina de la Comunidad de Madrid-B2017/BMD-3671-INFLAMUNE to FS-M, and ERC-2011-AdG294340-GENTRIS to FS-M. The Centro Nacional de Investigaciones Cardiovasculares (CNIC) is supported by the Spanish Ministry of Economy and Competitiveness (MINECO) and the Pro-CNIC Foundation and is a Severo Ochoa Center of Excellence (MINECOaward SEV-2015-0505). AR-G is supported by the FPU program (Spanish Ministry of Education). LF-M is funded by the CIBER CARDIOVASCULAR.
dc.language.isoeng
dc.publisherFrontiers Media 
dc.relation.isversionofPublisher's version
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectT cell activation
dc.subjectMicroRNAs (miRNAs)
dc.subjectImmunoregulatory molecules
dc.subjectmiRNA signature
dc.subjectCD4
dc.subjectCD8
dc.subjectT lymphocyte
dc.subjectEXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
dc.subjectSYSTEMIC-LUPUS-ERYTHEMATOSUS
dc.subjectMICRORNA-MEDIATED REGULATION
dc.subjectIMMUNE-RESPONSE
dc.subjectTGF-BETA
dc.subjectMULTIPLE-SCLEROSIS
dc.subjectRNA-INTERFERENCE
dc.subjectGENE-EXPRESSION
dc.subjectDOWN-REGULATION
dc.subjectCYTOKINE PRODUCTION
dc.titleControl of Immunoregulatory Molecules by miRNAs in T Cell Activation
dc.typeArtículo
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30319616
dc.format.volume9
dc.identifier.doi10.3389/fimmu.2018.02148
dc.contributor.funderMinisterio de Economía y Competitividad (España)
dc.contributor.funderCentro de Investigación Biomedica en Red - CIBER
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderComunidad de Madrid
dc.contributor.funderEuropean Research Council
dc.contributor.funderFundación ProCNIC
dc.contributor.funderMinisterio de Educación (España)
dc.contributor.funderEuropean Commission
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.3389/fimmu.2018.02148
dc.identifier.journalFrontiers in Immunology
dc.repisalud.orgCNICCNIC::Grupos de investigación::Comunicación Intercelular en la Respuesta Inflamatoria
dc.repisalud.institucionCNIC
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/294340es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccesses_ES


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