Please use this identifier to cite or link to this item:http://hdl.handle.net/20.500.12105/6532
Control of Immunoregulatory Molecules by miRNAs in T Cell Activation
Front Immunol. 2018; 9:2148
MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.
T cell activation | MicroRNAs (miRNAs) | Immunoregulatory molecules | miRNA signature | CD4 | CD8 | T lymphocyte | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | MICRORNA-MEDIATED REGULATION | IMMUNE-RESPONSE | TGF-BETA | MULTIPLE-SCLEROSIS | RNA-INTERFERENCE | GENE-EXPRESSION | DOWN-REGULATION | CYTOKINE PRODUCTION
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