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dc.contributor.authorCasquero-Veiga, Marta
dc.contributor.authorGarcía-García, David
dc.contributor.authorPascau, Javier
dc.contributor.authorDesco, Manuel 
dc.contributor.authorSoto-Montenegro, Maria Luisa
dc.date.accessioned2018-10-26T07:59:25Z
dc.date.available2018-10-26T07:59:25Z
dc.date.issued2018
dc.identifierISI:000445907400100
dc.identifier.citationPLoS One. 2018; 13(9):e0204740
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/20.500.12105/6531
dc.description.abstractPurpose The nucleus accumbens (NAcc) has been suggested as a possible target for deep brain stimulation (DBS) in the treatment of obesity. Our hypothesis was that NAcc-DBS would modulate brain regions related to reward and food intake regulation, consequently reducing the food intake and, finally, the weight gain. Therefore, we examined changes in brain glucose metabolism, weight gain and food intake after NAcc-DBS in a rat model of obesity. Procedures Electrodes were bilaterally implanted in 2 groups of obese Zucker rats targeting the NAcc. One group received stimulation one hour daily during 15 days, while the other remained as control. Weight and daily consumption of food and water were everyday registered the days of stimulation, and twice per week during the following month. Positron emission tomography (PET) studies with 2-deoxy-2-[F-18] fluoro-D-glucose (FDG) were performed 1 day after the end of DBS. PET data was assessed by statistical parametric mapping (SPM12) software and region of interest (ROI) analyses. Results NAcc-DBS lead to increased metabolism in the cingulate-retrosplenial-parietal association cortices, and decreased metabolism in the NAcc, thalamic and pretectal nuclei. Furthermore, ROIs analyses confirmed these results by showing a significant striatal and thalamic hypometabolism, and a cortical hypermetabolic region. However, NAcc-DBS did not induce a decrease in either weight gain or food intake. Conclusions NAcc-DBS led to changes in the metabolism of regions associated with cognitive and reward systems, whose impairment has been described in obesity.
dc.description.sponsorshipThis research was supported by the Ministry of Economy and Competitiveness ISCIII grants (PI14/00860, CPII14/00005), Ministry of Economy, Industry and Competitiveness (PI17/01766), cofunded by ERDF (FEDER) Funds from the European Commission ``A way of making Europe´´, Fundacion Mapfre, Fundacion Alicia Koplowitz (FAK2016/01), `Delegacion de Gobierno para el Plan Nacional sobre Drogas' (PNSD 2017/085), Comunidad de Madrid (BRADE-CM S2013/ICE-2958) and Fundacion Tatiana Perez de Guzman el Bueno. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.language.isoeng
dc.publisherPublic Library of Science (PLOS) 
dc.type.hasVersionVoR
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectMESOLIMBIC DOPAMINE SYSTEM
dc.subjectSPRAGUE-DAWLEY RATS
dc.subjectSMALL-ANIMAL PET
dc.subjectRETROSPLENIAL CORTEX
dc.subjectCLINICAL ARTICLE
dc.subjectREWARD CIRCUITRY
dc.subjectNETWORK ACTIVITY
dc.subjectZUCKER RATS
dc.subjectLEPTIN
dc.subjectMEMORY
dc.titleStimulating the nucleus accumbens in obesity: A positron emission tomography study after deep brain stimulation in a rodent model
dc.typejournal article
dc.rights.licenseAtribución 4.0 Internacional*
dc.identifier.pubmedID30261068
dc.format.volume13
dc.identifier.doi10.1371/journal.pone.0204740
dc.contributor.funderInstituto de Salud Carlos III 
dc.contributor.funderMinisterio de Economía, Industria y Competitividad (España) 
dc.contributor.funderUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) 
dc.contributor.funderFundación Mapfre 
dc.contributor.funderFundación Alicia Koplowitz 
dc.contributor.funderPlan Nacional de Drogas (España) 
dc.contributor.funderComunidad de Madrid (España) 
dc.contributor.funderFundación Tatiana Pérez de Guzmán el Bueno 
dc.description.peerreviewed
dc.relation.publisherversionhttps://doi.org/10.1371/journal.pone.0204740
dc.identifier.journalPLoS ONE
dc.repisalud.orgCNICCNIC::Unidades técnicas::Imagen Avanzada
dc.repisalud.institucionCNIC
dc.rights.accessRightsopen accesses_ES


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Atribución 4.0 Internacional
Este Item está sujeto a una licencia Creative Commons: Atribución 4.0 Internacional